Tag Archives: Randomized Controlled Trials

Inhaled Steroids to Prevent BPD? Think again… again!

Posted on 16 January 2018 by Keith Barrington

The NEUROSIS trial that I discussed in my previous post has, among other published trials, most in common with the trial by Nakamura published in 2016. Nakamura T, et al. Early inhaled steroid use in extremely low birthweight infants: a … Continue reading →

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Inhaled steroids to prevent BPD? Think again…

Posted on 15 January 2018 by Keith Barrington

The NEUROSIS trial was a high quality trial of inhaled budesonide started before 12 hours in extremely preterm infants (23 to <28 weeks gestation) receiving positive pressure respiratory support. The primary outcome of the trial was survival without needing oxygen … Continue reading →

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The last word on delayed cord clamping in the preterm? Part 2.

Posted on 8 November 2017 by Keith Barrington

I mentioned the second trial I wanted to discuss at the beginning of part 1. Duley L, et al. Randomised trial of cord clamping and initial stabilisation at very preterm birth. Archives of disease in childhood Fetal and neonatal edition. … Continue reading →

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The last word on delayed cord clamping for preterms? Part 1.

Posted on 7 November 2017 by Keith Barrington

The APTS (Australian placental transfusion study) trial has just appeared on line. This was a high-quality multicenter, international RCT of immediate cord clamping (less than 10 seconds) compared to delayed clamping (60 seconds) for babies born less than 32 weeks … Continue reading →

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Probiotics for extremely preterm infants

Posted on 25 May 2017 by Keith Barrington

The use of probiotics for Necrotising enterocolitis prophylaxis in the very preterm is increasing across Canada. There are apparently, though, centers that will only give them to larger preterm infants, and not to the most immature. I think that is … Continue reading →

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The CAP babies are now 11

Posted on 25 April 2017 by Keith Barrington

I was privileged to be part of the CAP trial group, a pivotal neonatal trial that showed improved Bayley scores and improved motor function at 18 to 21 months corrected age, among infants randomized before 10 days of age, with … Continue reading →

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Are preterm babies frequently Iodine deficient?

Posted on 19 April 2017 by Keith Barrington

Williams F, et al. Supplemental Iodide for Preterm Infants and Developmental Outcomes at 2 Years: an RCT. Pediatrics. 2017. We all need some iodine in order to make thyroid hormones (iodine doesn’t actually do anything else for us as far … Continue reading →

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Early low dose hydrocortisone seems to not affect medium term development; PREMILOC outcomes at 22 months.

Posted on 18 April 2017 by Keith Barrington

The PREMILOC trial was a multi-center RCT of hydrocortisone, 0.5mg/kg twice per day for 7 days followed by 0.5 mg/kg per day for 3 days, given starting within 24 hours of age to infants of 24 to less than 28 … Continue reading →

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Fluid restriction to prevent BPD?

Posted on 14 February 2017 by Keith Barrington

In response to my previous post, one of the comments was a question about fluid volumes in the first few days of life, and whether fluid and/or sodium intake was important for the development of BPD during the early neonatal … Continue reading →

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Fluid restriction as treatment for BPD? This time with the summary of findings table.

Posted on 13 February 2017 by Keith Barrington

I realize that many of my gentle readers may not have access to the Cochrane reviews in full text as soon as they are published. The NICHD do provide free access to the neonatal reviews, (together with a useful introduction … Continue reading →

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