Tag Archives: Systematic Reviews

Erythropoietin for brain protection in the very preterm? Not worth Penuts.

That isn’t a mis-spelling, just a bad attempt to play with the acronym for a good trial; the PENUT trial, just published in the (FP)NEJM. (Juul SE, et al. A Randomized Trial of Erythropoietin for Neuroprotection in Preterm Infants. N … Continue reading

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Progesterone doesn’t prevent prematurity?

Progesterone analogues, including 17-OH progesterone caproate have been investigated over the last several years for prevention of prematurity. In the pivotal trial from 2003 17OHPC intramuscularly once per week was shown to reduce prematurity at less than 37 weeks, less … Continue reading

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How fast to feed?

One of the recurring themes in this blog is that good, large enough, prospective RCTs do not necessarily reproduce the results of prior smaller trials, and often do not reproduce the findings of observational studies. Specifically, I have mentioned previously … Continue reading

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What respiratory outcomes are important?

When bronchopulmonary dysplasia was first described by Northway in 1967 he didn’t try to produce a definition, his paper was a description of a small number of preterm survivors of high oxygen and positive pressure ventilation. He noted some years … Continue reading

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Putting steroids in the lungs? Still unclear if it is safe or effective.

Systematic reviews, and meta-analyses should help us make a clinical decision, by accumulating all the evidence, determining its quality, and synthesizing impacts, we can then decide which therapeutic option to pursue. This latest review answers the following question “should I … Continue reading

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Clunk/click every hip

For those of you who are not of a certain age, and brought up in England, that title will not mean very much. When seat belts in cars were first made compulsory in the UK there was a widely quoted … Continue reading

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Oxygen for preterm infants, what dose of this toxic drug is the right dose? #NeoEBM

The NeoProm primary publication is the result of a prolonged gestation; I remember meetings over 15 years ago when Cynthia Cole from Boston was suggesting the idea, and although she was not, I think, finally an author on any of … Continue reading

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