Tag Archives: oxygen therapy

Oxygen is toxic in older kids too!

Posted on 22 February 2024 by Keith Barrington

A new large RCT from PICUs in the UK randomly compared 2 saturation target ranges, 88-92 and >94%. (Peters MJ, et al. Conservative versus liberal oxygenation targets in critically ill children (Oxy-PICU): a UK multicentre, open, parallel-group, randomised clinical trial. … Continue reading →

Posted in Neonatal Research | Tagged , , | 4 Comments

Automated oxygen control, what’s taking so long?

Posted on 29 April 2022 by Keith Barrington

A long long time ago, in a galaxy… actually quite near here, the idea of servo control of inspired oxygen was already in the air. At the time I first heard about it, the idea was to control FiO2 based … Continue reading →

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Omega-3 fatty acids, hype, and hope, and disappointment.

Posted on 7 August 2020 by Keith Barrington

Omega-3 fatty acids seem to be important for many functions, and currently many babies, especially preterm babies appear to be deficient compared to babies born at term. There has been much research into these dietary components, and they certainly are … Continue reading →

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Oxygen for resuscitation of the very preterm

Posted on 17 December 2019 by Keith Barrington

One of the paradoxes of neonatal respiratory control physiology is that hypoxia depresses respiration whilst hyperoxia stimulates breathing efforts. In fact it’s not such a paradox, prolonged hypoxia in adults decreases respiratory drive also. But could this be relevant in … Continue reading →

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Just do it! Who should go home on oxygen?

Posted on 15 May 2019 by Keith Barrington

A new guideline from the ATS has been published, which gives guidelines for home oxygen therapy for children, one large group of which is, of course, babies with bronchopulmonmary dysplasia. Hayes D, Jr., et al. Home Oxygen Therapy for Children. … Continue reading →

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Oxygen for preterm infants, what dose of this toxic drug is the right dose? #NeoEBM

Posted on 20 June 2018 by Keith Barrington

The NeoProm primary publication is the result of a prolonged gestation; I remember meetings over 15 years ago when Cynthia Cole from Boston was suggesting the idea, and although she was not, I think, finally an author on any of … Continue reading →

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PAS 2018: the wrap-up.

Posted on 14 May 2018 by Keith Barrington

A general comment about these PAS 2018 blog posts. I think we should be very careful about changing practice based on an abstract. We should respect peer review, with all its limitations, and we should always consider new research in … Continue reading →

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Too much oxygen is bad for adults too!

Posted on 2 May 2018 by Keith Barrington

The systematic review of the neonatal oxygen saturation targeting trials Askie LM, et al. Effects of targeting lower versus higher arterial oxygen saturations on death or disability in preterm infants. Cochrane database of systematic reviews (Online). 2017;4:Cd011190. confirmed the increase … Continue reading →

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I want a Guarantee.

Posted on 26 May 2016 by Keith Barrington

Enomoto M, et al. Effect of Volume Guarantee in Preterm Infants on High-Frequency Oscillatory Ventilation: A Pilot Study. American journal of perinatology. 2016(EFirst). One of the things that really bugs me (and there are many, as my gentle readers will … Continue reading →

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Still more doubts about BOOSTing saturations?

Posted on 22 February 2016 by Keith Barrington

I won’t make a point-by-point response to Reese’s comments, mostly because I agree with most of them! Oxygen is toxic. Minimizing oxygen toxicity is a vitally important issue. Alarm fatigue is a major problem. In our NICU we performed an … Continue reading →

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