Tag Archives: mortality

Intestinal perforation in the very preterm, what causes it, and what to do about it.

There are 2 main causes of intestinal perforation in the very preterm, Necrotising Enterocolitis and Spontaneous Perforation. NEC, as I have previously discussed, may be a convenient name for a few different conditions which present in a similar fashion. In … Continue reading

Posted in Neonatal Research | Tagged , , , , | Leave a comment

Extreme preterm survival and outcomes

There are frequently publications about the outcomes of extreme preterm infants; as a community I think we should be proud of our investment in outcome research. Indeed, neonatologists invented the entire field of outcomes research (Barrington KJ, Saigal S. Long-term … Continue reading

Posted in Neonatal Research | Tagged , | Leave a comment

The ACOG patient information page; what should it say about 22, 23, 24 weekers?

I mentioned not so long ago that the web page of the US Obstetricians professional association has information for prospective parents of babies of less than 25 weeks gestation that is… questionable. They state, for example, the following : Medical … Continue reading

Posted in Neonatal Research | Tagged , | 7 Comments

Outcomes of infants born at 22 weeks gestation; attitudes are the best predictor of survival

Among the most immature infants, mortality and morbidity are common even if they receive active neonatal intensive care, a new systematic review has attempted to find out how common. Backes CH, et al. Proactive Neonatal Treatment at 22 Weeks of … Continue reading

Posted in Neonatal Research | Tagged , , | 2 Comments

What to do about early postnatal steroids?

Steroid metabolism in the very immature infant is… immature. Adrenal function is still developing in the fetus between 20 and 26 weeks, and a source of precursors from the placenta is important, but obviously disappears at delivery. Very preterm babies … Continue reading

Posted in Neonatal Research | Tagged , , , , | 2 Comments

The jaundiced eye of the beholder

Well, this is disappointing, the amazing results from Iowa regarding the outcomes of infants born at 22 and at 23 weeks gestation have now been published in the February print edition of the Journal of Pediatrics. What is disappointing about … Continue reading

Posted in Neonatal Research | Tagged | 2 Comments

Giving bad news as it happens

A new publication from my great group at Sainte Justine. Lizotte MH, et al. Techniques to Communicate Better With Parents During End-of-Life Scenarios in Neonatology. Pediatrics. 2020:e20191925. We have already published about what residents think about being part of a … Continue reading

Posted in Neonatal Research | Tagged , , | Leave a comment

Erythropoietin for brain protection in the very preterm? Not worth Penuts.

That isn’t a mis-spelling, just a bad attempt to play with the acronym for a good trial; the PENUT trial, just published in the (FP)NEJM. (Juul SE, et al. A Randomized Trial of Erythropoietin for Neuroprotection in Preterm Infants. N … Continue reading

Posted in Neonatal Research | Tagged , , , , | 2 Comments

International variations in outcomes of extreme preterm infants

A publication from an international collaboration of neonatal databases has just appeared, (Lui K, et al. Trends in Outcomes for Neonates Born Very Preterm and Very Low Birth Weight in 11 High-Income Countries. J Pediatr. 2019). It makes very interesting … Continue reading

Posted in Neonatal Research | Tagged , , | 1 Comment

Platelet transfusion threshholds: 25,000 even for the highest risk infants?

The Planet-2 trial that I posted about when it first came out showed no benefit among preterm infants, <34 weeks gestation when they received platelet transfusions at a threshold of 50,00 compared to waiting until they dropped to 25,000. I … Continue reading

Posted in Neonatal Research | Tagged , , | Leave a comment