Tag Archives: PDA

PAS 2018 No3: Should we TOLERATE the PDA?

This was another large multicenter trial, designed to determine if routine attempts to close a moderate to large PDA at the end of the first postnatal week decreases the duration of patency, and the incidence of the combined outcome “need … Continue reading

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Paracetamol for the PDA? Maybe not, this time.

Roofthooft DW, et al. Limited effects of intravenous paracetamol on patent ductus arteriosus in very low birth weight infants with contraindications for ibuprofen or after ibuprofen failure. Eur J Pediatr. 2015:1-8. In contrast to the previous study that I blogged … Continue reading

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Paracetamol for the PDA?

EL-Khuffash A, et al. Late medical therapy of patent ductus arteriosus using intravenous paracetamol. Archives of Disease in Childhood – Fetal and Neonatal Edition. 2015;100(3):F253-F6. (CoI statement: The authors of this paper are friends, colleagues and collaborators of mine), the … Continue reading

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Reassuring Prophylactic Indomethacin Data

One of Annie Janvier’s first research projects was a case control study of the influence of prophylactic indomethacin on intestinal perforations. Under my supervision she analyzed cases of spontaneous intestinal perforation (SIP), and we analyzed the influence of prophylactic indomethacin, … Continue reading

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Can Paracetamol (acetaminophen) close the ductus arteriosus?

A new publication by Afif El-Khuffash and his colleagues (El-Khuffash A et al. Efficacy of paracetamol on patent ductus arteriosus closure may be dose dependent: evidence from human and murine studies. Pediatr Res. 2014;76(3):238-44) describes a retrospective review of paracetamol use in newborn … Continue reading

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Low Cardiac Output after PDA ligation

Some babies after PDA ligation develop a low cardiac output, Patrick McNamara and his colleagues have defined that as being less than 200 mL/kg/min left ventricular output. This cohort study of 30 infants post-ligation, by Afif El-Khuffash and colleagues at … Continue reading

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The PDA, indomethacin and pulmonary hemorrhages.

In a comment on a recent post, Martin Kluckow pointed out that they have just had published a moderately sized RCT. It was supposed to be larger, but intravenous indomethacin became unavailable, so they had to stop the trial. (Kluckow … Continue reading

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PDA shunts and extubation

Following on from my recent post about PEEP levels and PDA shunts, this new article from Perth. The authors prospectively enrolled very immature infants (< 28 weeks) before a planned early extubation and did echocardiograms before and after. The mean … Continue reading

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PEEP and ductal shunts

I never thought that modest increase in PEEP would have a real effect on ductal shunting. As the size of the ductal shunt depends on the pressure gradient across the PDA and the resistance of the vessel, in order to … Continue reading

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Feeding during PDA treatment

Ron Clyman and a multicenter group have just published this DAFFII trial. Which is a rather tortuous light-hearted acronym for Ductus Arteriosus Feed or Fast with Indomethcain or Ibuprofen.   (Clyman R, Wickremasinghe A, Jhaveri N, Hassinger DC, Attridge JT, Sanocka … Continue reading

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