Tag Archives: PDA

PAS 2018 No3: Should we TOLERATE the PDA?

Posted on 10 May 2018 by Keith Barrington

This was another large multicenter trial, designed to determine if routine attempts to close a moderate to large PDA at the end of the first postnatal week decreases the duration of patency, and the incidence of the combined outcome “need … Continue reading →

Posted in Neonatal Research | Tagged , , | 2 Comments

Paracetamol for the PDA? Maybe not, this time.

Posted on 15 May 2015 by Keith Barrington

Roofthooft DW, et al. Limited effects of intravenous paracetamol on patent ductus arteriosus in very low birth weight infants with contraindications for ibuprofen or after ibuprofen failure. Eur J Pediatr. 2015:1-8. In contrast to the previous study that I blogged … Continue reading →

Posted in Neonatal Research | Tagged | 2 Comments

Paracetamol for the PDA?

Posted on 26 April 2015 by Keith Barrington

EL-Khuffash A, et al. Late medical therapy of patent ductus arteriosus using intravenous paracetamol. Archives of Disease in Childhood – Fetal and Neonatal Edition. 2015;100(3):F253-F6. (CoI statement: The authors of this paper are friends, colleagues and collaborators of mine), the … Continue reading →

Posted in Neonatal Research | Tagged | 1 Comment

Reassuring Prophylactic Indomethacin Data

Posted on 28 October 2014 by Keith Barrington

One of Annie Janvier’s first research projects was a case control study of the influence of prophylactic indomethacin on intestinal perforations. Under my supervision she analyzed cases of spontaneous intestinal perforation (SIP), and we analyzed the influence of prophylactic indomethacin, … Continue reading →

Posted in Neonatal Research | Tagged , | Leave a comment

Can Paracetamol (acetaminophen) close the ductus arteriosus?

Posted on 29 September 2014 by Keith Barrington

A new publication by Afif El-Khuffash and his colleagues (El-Khuffash A et al. Efficacy of paracetamol on patent ductus arteriosus closure may be dose dependent: evidence from human and murine studies. Pediatr Res. 2014;76(3):238-44) describes a retrospective review of paracetamol use in newborn … Continue reading →

Posted in Neonatal Research | Tagged | Leave a comment

Low Cardiac Output after PDA ligation

Posted on 22 May 2014 by Keith Barrington

Some babies after PDA ligation develop a low cardiac output, Patrick McNamara and his colleagues have defined that as being less than 200 mL/kg/min left ventricular output. This cohort study of 30 infants post-ligation, by Afif El-Khuffash and colleagues at … Continue reading →

Posted in Neonatal Research | Tagged , | 1 Comment

The PDA, indomethacin and pulmonary hemorrhages.

Posted on 15 December 2013 by Keith Barrington

In a comment on a recent post, Martin Kluckow pointed out that they have just had published a moderately sized RCT. It was supposed to be larger, but intravenous indomethacin became unavailable, so they had to stop the trial. (Kluckow … Continue reading →

Posted in Neonatal Research | Tagged , , , | 1 Comment

PDA shunts and extubation

Posted on 12 December 2013 by Keith Barrington

Following on from my recent post about PEEP levels and PDA shunts, this new article from Perth. The authors prospectively enrolled very immature infants (< 28 weeks) before a planned early extubation and did echocardiograms before and after. The mean … Continue reading →

Posted in Neonatal Research | Tagged , | 2 Comments

PEEP and ductal shunts

Posted on 9 December 2013 by Keith Barrington

I never thought that modest increase in PEEP would have a real effect on ductal shunting. As the size of the ductal shunt depends on the pressure gradient across the PDA and the resistance of the vessel, in order to … Continue reading →

Posted in Neonatal Research | Tagged , , | Comments Off on PEEP and ductal shunts

Feeding during PDA treatment

Posted on 15 October 2013 by Keith Barrington

Ron Clyman and a multicenter group have just published this DAFFII trial. Which is a rather tortuous light-hearted acronym for Ductus Arteriosus Feed or Fast with Indomethcain or Ibuprofen.   (Clyman R, Wickremasinghe A, Jhaveri N, Hassinger DC, Attridge JT, Sanocka … Continue reading →

Posted in Neonatal Research | Tagged , , , , | Leave a comment