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Meta
Monthly Archives: August 2013
Blurring the line between patients and research subjects
The US Department of Health and Human Services held a public meeting about consent issues for research on August the 28th, largely as a result of the controversy surrounding SUPPORT. It was called ‘Matters Related to Protection of Human Subjects … Continue reading
Posted in Neonatal Research
4 Comments
Comparative Effectiveness Research: a parable
Two neonatologists work in the same NICU. One of them routinely starts assisted ventilation of babies with volume ventilation, the other starts with pressure ventilation. There is controversy in the literature and in practice among currently active neonatologists; some preliminary … Continue reading
Posted in Neonatal Research
Tagged Ethics, Randomized Controlled Trials, Respiratory Management
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Is volume ventilation really better?
A systematic review published in 2011 of the studies comparing pressure to volume ventilation stated that there was ‘reduced death/BPD, duration of ventilation, pneumothoraces, hypocarbia and periventricular leukomalacia/severe intraventricular hemorrhage’ using volume targeted ventilation.’ I think it may be true that volume ventilation … Continue reading
Is cows milk just for cows?
A new publication from the trial funded by Prolacta looking at possible benefits of their donor-human-milk derived preparations. This time it is the other comparison from the registered trial. That is; mothers who did not plan to breast feed were approached to … Continue reading
We didn’t find what we wanted to find, so we thought we’d re-analyze the data until we found it.
…oh and by the way, we are the manufacturers making the product in question, so we had objective scientific reasons for doing this, no conflict of interest whatever. The commercial sponsors of a negative trial decided that they didn’t like … Continue reading
Public Citizen are a public danger: part 2
The other part of the criticisms of Public Citizen, included in their letter to the secretary of the HSS in the USA, in which they call for the TOP (transfusion of preterms) trial to be stopped immediately, are regarding the … Continue reading
Posted in Neonatal Research
Tagged Ethics, Randomized Controlled Trials, transfusion
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Public Citizen are a public danger: part 1
They are at it again. The people in the Public Citizen health research group don’t understand evidence based practice, they don’t understand clinical research and they don’t understand neonatology. Which doesn’t stop them from making a fuss about high quality … Continue reading
Posted in Neonatal Research
Tagged Ethics, Randomized Controlled Trials, transfusion
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More about SUPPORT, but this time not the consent forms
The main, surprising, finding of SUPPORT, now confirmed by the other oxygen trials, is that aiming for O2 saturations that were a little lower led to higher mortality. The big question is why? Having a saturation of 85% to 90% … Continue reading
Who should get surfactant?
I think the literature is clear, if you need surfactant, the earlier you get it the better. If you don’t need surfactant you are better off never being intubated. So how do we decide? Current management protocols usually put babies … Continue reading
Posted in Neonatal Research
Tagged BPD, CPAP, endotracheal intubation, Randomized Controlled Trials, surfactant treatment
2 Comments
Neonatal Research 