Author Archives: keithbarrington

About keithbarrington

I am a neonatologist and clinical researcher at Sainte Justine University Health Center in Montréal

Linezolid seems safe for preterms, probably

A few years ago we started having difficulty clearing Coagulase-Negative Staphylococcal (CoNS) sepsis from the blood cultures of some babies in our NICU, children with CoNS also seemed to be sicker, and to more often have thrombocytopenia. It was at … Continue reading

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What to do about early postnatal steroids?

Steroid metabolism in the very immature infant is… immature. Adrenal function is still developing in the fetus between 20 and 26 weeks, and a source of precursors from the placenta is important, but obviously disappears at delivery. Very preterm babies … Continue reading

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We are all treaty peoples

We are all treaty peoples if we live in North America! We, at least the “we” who are concerned about such things, have a tendency to think that the treaty people are only the aboriginal descendants of those who had … Continue reading

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They really are CRAP! C-ReActive Protein: “Hazardous Waste”.

I have railed against the use of C-Reactive Protein, CRP, on this blog previously, it was my analysis that the CRP is sensitive, but with very poor specificity, both for early-onset sepsis, and for late-onset sepsis. A new systematic review … Continue reading

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What is hypoglycaemia? Part 3. Part of the answer!

The only way that we can find the answer to the question of what threshold blood sugar we should use to treat babies with low blood sugars is a prospective RCT, and Behold! Look! Lo! How say you? (van Kempen … Continue reading

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What is hypoglycemia? part 2

The new statement from the CPS, and many others, don’t discuss which measurement that we are really interested in, is it blood glucose, or plasma glucose? The different data sources are discussed as if they were all measuring the same … Continue reading

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What is hypoglycaemia? Part 1.

The Canadian Pediatric Society has just published new guidance for screening and treatment of infants at risk for neonatal hypoglycaemia. The older statement needed to be revised, in particular to include the use of oral glucose gel as an option, … Continue reading

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