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Author Archives: keithbarrington
Therapeutic Hypothermia post cardiac arrest
This is a bit off-topic for this blog, but many of you will know that cooling is now used for many other patients than just our full-term asphyxias. Adults who remain with depressed levels of consciousness after resuscitation from a … Continue reading
International variations in outcomes of extreme preterm infants
A publication from an international collaboration of neonatal databases has just appeared, (Lui K, et al. Trends in Outcomes for Neonates Born Very Preterm and Very Low Birth Weight in 11 High-Income Countries. J Pediatr. 2019). It makes very interesting … Continue reading
Posted in Neonatal Research
Tagged intracranial hemorrhage, mortality, Retinopathy of Prematurity
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Platelet transfusion threshholds: 25,000 even for the highest risk infants?
The Planet-2 trial that I posted about when it first came out showed no benefit among preterm infants, <34 weeks gestation when they received platelet transfusions at a threshold of 50,00 compared to waiting until they dropped to 25,000. I … Continue reading
Posted in Neonatal Research
Tagged mortality, Platelets, Randomized Controlled Trials
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Diazoxide for hyperinsulinism? Not so fast
Infants with congential persistent hyperinsulinism have been treated for years with diazoxide, well before many of the genetic mutations underlying the condition were known (there are now at least 14 of them!). Diazoxide seems to be relatively well tolerated in … Continue reading
Donor human milk for congenital heart disease?
Newborns with serious Congenital Heart Disease are at risk of intestinal injury which may present in a similar fashion to Necrotising Enterocolitis (NEC). Our local guidelines for eligibility for donor milk from our provincial milk bank include infants with significant … Continue reading
Posted in Neonatal Research
Tagged breast milk, Congenital Heart Disease, Necrotising Enterocolitis
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Where does sepsis come from?
One of the findings of the recent SIFT trial was that although the babies in the fast feeding group had shorter duration of parenteral nutrition, TPN, (and presumably of central lines), they did not have less late-onset sepsis, LOS. Why … Continue reading
Posted in Neonatal Research
Tagged enteral feeding, infection control, microbiome, Sepsis
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Progesterone doesn’t prevent prematurity?
Progesterone analogues, including 17-OH progesterone caproate have been investigated over the last several years for prevention of prematurity. In the pivotal trial from 2003 17OHPC intramuscularly once per week was shown to reduce prematurity at less than 37 weeks, less … Continue reading
