Tag Archives: Randomized Controlled Trials

Probiotics and NEC, the latest answer?

The updated Cochrane review of probiotics for prevention of NEC, sepsis and mortality has been published. Meta-analysis showed that probiotics may reduce the risk of NEC: RR 0.54, 95% CI 0.45 to 0.65 (54 trials, 10,604 infants; I2 = 17%); … Continue reading

Posted in Neonatal Research | Tagged , , , | 1 Comment

What happened to the HeROs?

I had to find a way of changing HeRO to Heroes as an excuse for posting a link to this video But also the results of a long term follow up of the HeRO trial have been published. The original … Continue reading

Posted in Neonatal Research | Tagged , , | Leave a comment

Breast milk fortifiers, a new systematic review

A systematic review has just been published which compares the outcomes of milk fortification with bovine-milk derived fortifier and human-milk derived fortifier. (Grace E, et al. Safety and efficacy of human milk-based fortifier in enterally fed preterm and/or low birthweight … Continue reading

Posted in Neonatal Research | Tagged , , , , | 6 Comments

Evidence-Based Neonatology: more and more evidence, better and better care

For another project, which I will explain later, I have been trying to find recent large multicentre trials in very preterm babies. I searched PubMed for “Randomized Controlled Trial’, and “Multicentre study”, then filtered by Human and Newborn and Preterm … Continue reading

Posted in Neonatal Research | Tagged | 7 Comments

Does LISA protect your brain?

A few years ago now a multicenter RCT among infants of 23 to 26 weeks gestation showed that LISA was possible in even these most immature infants., NINSAPP. Kribs A, et al. Nonintubated Surfactant Application vs Conventional Therapy in Extremely … Continue reading

Posted in Neonatal Research | Tagged , , | 1 Comment

Delayed cord clamping in the very preterm

I haven’t written about this issue in a while, the APTS trial, and the systematic review which was published at about the same time appeared to show definitively that there was a reduction in mortality with delayed clamping compared to … Continue reading

Posted in Neonatal Research | Tagged , , | 1 Comment

Diagnosing seizures in the newborn: a small step forward

The use of continuous EEG has become much more frequent in the NICU in recent years. It has become clear that clinical recognition of seizures, both those with and without clinical convulsions (which I will call electrographic seizures for all … Continue reading

Posted in Neonatal Research | Tagged , , | Leave a comment

Dexamethasone ENT doses

Although we have a great group of ENT surgeons at my hospital, we do have one bone of contention; at least, there is just one bone left since they have agreed that you cannot diagnose reflux by performing a laryngoscopy! … Continue reading

Posted in Neonatal Research | Tagged , , , | 1 Comment

Lactoferrin: Does it decrease late-onset sepsis?

The first multicentre trial of bovine lactoferrin supplementation in preterm infants showed a dramatic reduction in late-onset sepsis of about 70%. I was very excited when I first saw Paolo Manzoni’s trial and rushed to set up a pilot in … Continue reading

Posted in Neonatal Research | Tagged , , , | Leave a comment

When should we start Parenteral Nutrition?

Following on from the previous post: This all brings me to a larger and very thorny issue, which is whether we should even be routinely starting parenteral nutrition (PN) immediately after birth at all! I hate to discuss this, as … Continue reading

Posted in Neonatal Research | Tagged , , , | 1 Comment