Tag Archives: Randomized Controlled Trials

RCTs prevail: Antibiotic impregnation of central lines doesn’t reduce sepsis.

In older children and adults who need central venous access, using catheters impregnated with stuff that kills bugs decreases invasive sepsis rates. A multicentre trial in English PICUs showed a reduction in sepsis from 4% to 1% when antibiotic impregnated … Continue reading

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Insulin like growth factor: does it prevent BPD, or does it increase RoP and mortality?

In the March print edition of the Journal of Pediatrics, the report of the Insulin-like growth factor 1/IGF binding protein 3 trial, as a preventive for retinopathy. Ley D, et al. rhIGF-1/rhIGFBP-3 in Preterm Infants: A Phase 2 Randomized Controlled … Continue reading

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Measure gastric residuals? Safe to stop?

A new RCT published in JAMA pediatrics compared growth and other clinical outcomes between infants <33 weeks gestation and <1250g who were managed with routine gastric residual measurements or without. (Parker LA, et al. Effect of Gastric Residual Evaluation on … Continue reading

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Platelet transfusions don’t close the PDA, but they may increase IVH

I would never have actually thought to ask the question whether platelet transfusion might close the PDA, although early thrombocytopenia is associated with persistent PDA, and platelet plugs seem to be part of the mechanism of closure. A group in … Continue reading

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Death or oxygen, which is worse?

We have a big problem in neonatal research. We have constructed composite outcomes that have become the “standard of design”, but are not of much use for anyone. Because we are, rightly, concerned that death and other diagnoses may be … Continue reading

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Under Pressure…

This post “under pressure” isn’t about the classic collaboration between David Bowie and Queen at Live Aid, rather it is about how to wean CPAP. Should we trial preterm babies off for a period every day, or either progressively reduce … Continue reading

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Heads up?

A new RCT published in the Journal of Perinatology suggests that a midline head position with head elevated at 30 degrees might reduce severe intracranial hemorrhage. (Kochan M, et al. Elevated midline head positioning of extremely low birth weight infants: … Continue reading

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