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Meta
Tag Archives: Randomized Controlled Trials
PAS report 2024: Clinical Trials part 2
The NeoGluCO trial This trial was a modestly sized RCT of low dose diazoxide for treatment of persistent or severe hypoglycaemia in newborn infants of at least 35 weeks gestation. I say “modestly sized” as a descriptor, not a criticism, … Continue reading
PAS report 2024: Clinical Trials part 1.
As usual the PAS meeting was packed with neonatology. The App was even worse than last year, crashing frequently on many peoples’ phones. It was completely useless for the posters, as they were listed by number, and the different sessions … Continue reading
When you can see what you are doing, you can see what you have done: Video-Laryngoscopy in the newborn
I have been increasingly using video laryngoscopy in my practice, both when I myself perform the intubation, and when I am supervising a resident or other trainee. I usually ask them to use a VL when it is a nurse … Continue reading
Posted in Neonatal Research
Tagged endotracheal intubation, Premedication, Preterm, Randomized Controlled Trials, Simulation
5 Comments
How should we pasteurize donor breast milk?
The standard method of pasteurization of donor breast milk, and I believe the only method approved by HMBANA (the human milk banking association of north america), is similar to what Louis Pasteur himself came up with a couple of centuries … Continue reading
Posted in Neonatal Research
Tagged breast milk, infection control, pasteurization, Randomized Controlled Trials, Sepsis
1 Comment
Oxygen is toxic in older kids too!
A new large RCT from PICUs in the UK randomly compared 2 saturation target ranges, 88-92 and >94%. (Peters MJ, et al. Conservative versus liberal oxygenation targets in critically ill children (Oxy-PICU): a UK multicentre, open, parallel-group, randomised clinical trial. … Continue reading
Posted in Neonatal Research
Tagged oxygen therapy, oxygen toxicity, Randomized Controlled Trials
4 Comments
Donor human milk, not toxic after all!
It was fairly recently that I deconstructed a truly terrible database analysis which claimed that neonatal mortality was dramatically increased among very preterm infants who received mother’s own milk (MoM) and donor human milk (DHM), without any formula or fortifier, … Continue reading
Is there any indication to close the PDA?
Yet another trial of PDA treatment and attempted closure with a null result. Baby-OSCAR was a UK multi-center masked RCT of ibuprofen treatment of 23 to <29 week infants who were screened with echocardiogram within the first 72 hours of … Continue reading
Time to open the DOOR
I have written many times about the problems with classical composite outcomes in neonatal research. “Death or BPD”, “death or NDI”, or sometimes “death or NEC or Sepsis or BPD or severe IVH” have been used as a way of … Continue reading
Which Probiotic is Preferable?
The word “probiotic” is defined rather vaguely as a micro-organism which has beneficial health impacts. I think it is obvious that there is a huge difference between fungi that are found in the intestinal microbiome of adults, and the lactic … Continue reading
Neonatal Research 