Tag Archives: Randomized Controlled Trials

Inhaled Steroids to Prevent BPD? Think again… again!

The NEUROSIS trial that I discussed in my previous post has, among other published trials, most in common with the trial by Nakamura published in 2016. Nakamura T, et al. Early inhaled steroid use in extremely low birthweight infants: a … Continue reading

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Inhaled steroids to prevent BPD? Think again…

The NEUROSIS trial was a high quality trial of inhaled budesonide started before 12 hours in extremely preterm infants (23 to <28 weeks gestation) receiving positive pressure respiratory support. The primary outcome of the trial was survival without needing oxygen … Continue reading

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The last word on delayed cord clamping in the preterm? Part 2.

I mentioned the second trial I wanted to discuss at the beginning of part 1. Duley L, et al. Randomised trial of cord clamping and initial stabilisation at very preterm birth. Archives of disease in childhood Fetal and neonatal edition. … Continue reading

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The last word on delayed cord clamping for preterms? Part 1.

The APTS (Australian placental transfusion study) trial has just appeared on line. This was a high-quality multicenter, international RCT of immediate cord clamping (less than 10 seconds) compared to delayed clamping (60 seconds) for babies born less than 32 weeks … Continue reading

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Probiotics for extremely preterm infants

The use of probiotics for Necrotising enterocolitis prophylaxis in the very preterm is increasing across Canada. There are apparently, though, centers that will only give them to larger preterm infants, and not to the most immature. I think that is … Continue reading

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The CAP babies are now 11

I was privileged to be part of the CAP trial group, a pivotal neonatal trial that showed improved Bayley scores and improved motor function at 18 to 21 months corrected age, among infants randomized before 10 days of age, with … Continue reading

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Are preterm babies frequently Iodine deficient?

Williams F, et al. Supplemental Iodide for Preterm Infants and Developmental Outcomes at 2 Years: an RCT. Pediatrics. 2017. We all need some iodine in order to make thyroid hormones (iodine doesn’t actually do anything else for us as far … Continue reading

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