Tag Archives: Randomized Controlled Trials

What to do about early postnatal steroids?

Steroid metabolism in the very immature infant is… immature. Adrenal function is still developing in the fetus between 20 and 26 weeks, and a source of precursors from the placenta is important, but obviously disappears at delivery. Very preterm babies … Continue reading

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What is hypoglycaemia? Part 3. Part of the answer!

The only way that we can find the answer to the question of what threshold blood sugar we should use to treat babies with low blood sugars is a prospective RCT, and Behold! Look! Lo! How say you? (van Kempen … Continue reading

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Erythropoietin for brain protection in the very preterm? Not worth Penuts.

That isn’t a mis-spelling, just a bad attempt to play with the acronym for a good trial; the PENUT trial, just published in the (FP)NEJM. (Juul SE, et al. A Randomized Trial of Erythropoietin for Neuroprotection in Preterm Infants. N … Continue reading

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Oropharyngeal airways for resuscitation of the preterm? Throw them away!

When I saw the title of this new study I thought immediately this has to either be by Peter Davis or one or more of his disciples… former trainees, I mean. In fact it is both: Kamlin COF, et al. … Continue reading

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Oxygen for resuscitation of the very preterm

One of the paradoxes of neonatal respiratory control physiology is that hypoxia depresses respiration whilst hyperoxia stimulates breathing efforts. In fact it’s not such a paradox, prolonged hypoxia in adults decreases respiratory drive also. But could this be relevant in … Continue reading

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Platelet transfusion threshholds: 25,000 even for the highest risk infants?

The Planet-2 trial that I posted about when it first came out showed no benefit among preterm infants, <34 weeks gestation when they received platelet transfusions at a threshold of 50,00 compared to waiting until they dropped to 25,000. I … Continue reading

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Progesterone doesn’t prevent prematurity?

Progesterone analogues, including 17-OH progesterone caproate have been investigated over the last several years for prevention of prematurity. In the pivotal trial from 2003 17OHPC intramuscularly once per week was shown to reduce prematurity at less than 37 weeks, less … Continue reading

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