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Tag Archives: Randomized Controlled Trials
PAS 2023, some supplemental selected stuff
As usual, the annual meeting of PAS had too many things going on simultaneously to be able to get to all the interesting looking neonatal research. But here are a few things, that were of interest to me, and which … Continue reading
Posted in Neonatal Research
Tagged BPD, budesonide, long term outcomes, Randomized Controlled Trials, surfactant treatment
1 Comment
PAS 2023, some selected stuff
Hernia repair timing One trial which will should have an on the care of newborn infants is the trial of early versus late hernia repair. 40 neonatal centres in the USA randomized 320 preterm infants to inguinal hernia repair before … Continue reading
Posted in Neonatal Research
Tagged asphyxia, Hypothermia, Inguinal Hernia, Randomized Controlled Trials
2 Comments
An ESCape route for infants suffering opiate withdrawal
The Finnegan score was developed and evaluated in the 1970’s as the first systematic way of monitoring babies going through perinatal drug withdrawal. Although it was an advance at the time, it was not developed using modern standards, and was … Continue reading
What now for cerebral NIRS in the preterm?
Previous randomized trials of routine cerebral NIRS in preterm infants have shown that cerebral hypoxia can be reduced by responding to the signal, but in an underpowered follow up of a subgroup, there was no impact on long term outcomes. … Continue reading
Comment on my post about the Beneductus trial
The authors of the Beneductus trial commented on my post about the trial, but it has somehow disappeared from the comment section of the blog, as they raise very valid points, I thought I would copy what they sent here … Continue reading
How much protein should we provide to the preterm in the first days of life?
Extremely preterm infants become catabolic rapidly after birth, with the sudden interruption of their trans-placental nutrient supply to the fetus, who becomes a baby that has tiny stores of fat or glycogen. We progressed in neonatology from starving preterm babies … Continue reading
It’s Raining Antibiotics
Early onset sepsis is a serious condition with a substantial morbidity, and, thankfully, a relatively low mortality in recent years. Prompt recognition and early treatment are essential, but early clinical signs and risk factors tend to be non-specific. As a … Continue reading
Posted in Neonatal Research
Tagged antibiotics, microbiome, Randomized Controlled Trials, Sepsis
3 Comments
Do omega 3 fatty acids make preterm babies smarter?
It seems that they do, perhaps a little bit! There are now a confusing array of trials of supplementation of polyunsaturated fatty acids in preterm infants. They have compared various control diets to differing PUFA supplements. Many of them have … Continue reading
Time to stop placebo injections in neonatal research projects
Randomized controlled trials are the bedrock of evidence-based medicine. If a treatment has a good theoretical rationale, and preclinical data showing efficacy, the only way to prove efficacy in the human is to randomise patients to the treatment, compared to … Continue reading
Reducing pain from retinopathy screening
Retinopathy screening is undoubtedly painful for preterm babies, formal evaluation with PIPP scores routinely exceed 10 during screening, and may exceed 14, meaning moderate to severe pain. As a planned procedure there is always opportunity for pre-emptive analgesia prior to … Continue reading
Neonatal Research 