Monthly Archives: November 2015

The best outcome variable for very preterm newborns?

Death or ‘neurodevelopmental impairment’ (NDI) as a combined outcome has become a sort of de facto standard as the primary outcome for neonatal clinical trials. Because many very preterm infants have developmental delay, intellectual and learning difficulties, and some have … Continue reading

Posted in Clinical Practice Guidelines, Neonatal Research | Tagged , , , | 1 Comment

An Oldie but a Goodie

I discovered several months ago that one of my older presentations is very difficult to get on-line. It seems that at some point, when this article, Barrington K, Finer N. The natural history of the appearance of apnea of prematurity. Pediatr … Continue reading

Posted in Neonatal Research | Tagged | Leave a comment

The last nail in the coffin of permissive hypercapnia?

Thome UH, et al. Permissive hypercapnia in extremely low birthweight infants (PHELBI): a randomised controlled multicentre trial. Lancet Respir Med. 2015;3(7):534-43. This German multi-center trial randomized infants 400 to 1000 g birth weight to 2 different CO2 target ranges. The … Continue reading

Posted in Neonatal Research | Tagged , | 1 Comment

Diaphragmatic Hernia Updates

There have been many publications recently for this group of our patients: Hagadorn JI, et al. Trends in treatment and in-hospital mortality for neonates with congenital diaphragmatic hernia. J Perinatol. 2015;35(9):748-54. This multi-center cohort study shows, in term babies, that … Continue reading

Posted in Neonatal Research | Tagged | Leave a comment

Conflicts of interest are not all financial, but they are conflicts none the less. Name change not required.

Another poorly argued article trying to minimize the reality of conflicts of interest in medical research. Cappola AR, FitzGerald GA. Confluence, not conflict of interest: Name change necessary. JAMA. 2015;314(17):1791-2. If someone stands to have a personal advantage as a result … Continue reading

Posted in Neonatal Research | Tagged , | Leave a comment

Retinopathy: up or down?

The oxygen saturation targeting trials showed more retinopathy with higher oxygen saturation targets. Will this translate into more retinopathy in actual practice? Many units have increased their saturation targets as a result of those studies. This may indeed lead to … Continue reading

Posted in Neonatal Research | Tagged , , | 3 Comments

Neonatal Updates

Gschließer A, et al. Inter-expert and Intra-expert Agreement on the Diagnosis and Treatment of Retinopathy of Prematurity. American Journal of Ophthalmology. 2015;160(3):553-60.e3. The investigators showed 52 retinal photographs to 7 expert ophthalmologists, and then 8 weeks later showed them to … Continue reading

Posted in Neonatal Research | Tagged , | Leave a comment