Monthly Archives: May 2021

Two amazing trials, at the opposite ends of the spectrum. What a weird world.

Posted on 27 May 2021 by Keith Barrington

In the most recent NEJM two trials impacting newborn/paediatric care. One including 3,211 preterm infants, which shows that a very simple intervention could save, I estimate, tens of thousands of lives each year at almost no cost; the other with … Continue reading →

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What do you think are meaningful long term outcomes for preterm infants? Give your opinion!

Posted on 13 May 2021 by Keith Barrington

Annie Janvier is part of a group of collaborators who are trying to get multiple opinions about meaningful outcomes in preterm babies. It is part of a project being run by the Canadian Follow-up Network CNFUN, which is called Parent-EPIQ. … Continue reading →

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Which is worse; death or a low Bayley score? Comparing composite outcomes between groups, taking into account clinical priorities.

Posted on 13 May 2021 by Keith Barrington

I keep harping on about this issue as I think we make a mistake in the design of our research studies when we include death and a much less important outcome in composite outcomes. For example in the STOP-BPD trial, … Continue reading →

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Renal Function in the very immature preterm, what is a “normal” creatinine

Posted on 12 May 2021 by Keith Barrington

The last time I blogged about this issue, there were a few comments from renal specialists which pointed out some limitations in my interpretation of the data. I defended myself admirably (it is my blog after all!) but I recognize … Continue reading →

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Longer-term outcomes: what should we measure? part 2

Posted on 5 May 2021 by Keith Barrington

I have made my concerns about developmental screening tests including the Bayley clear over the years, including in the previous post, which might make what I am going to say now seem odd: I do not think we should stop … Continue reading →

Posted in Neonatal Research | Tagged | 3 Comments