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Meta
Tag Archives: Necrotising Enterocolitis
Donor human milk, not toxic after all!
It was fairly recently that I deconstructed a truly terrible database analysis which claimed that neonatal mortality was dramatically increased among very preterm infants who received mother’s own milk (MoM) and donor human milk (DHM), without any formula or fortifier, … Continue reading
Which Probiotic is Preferable?
The word “probiotic” is defined rather vaguely as a micro-organism which has beneficial health impacts. I think it is obvious that there is a huge difference between fungi that are found in the intestinal microbiome of adults, and the lactic … Continue reading
Do probiotics only work in bigger babies? What is the risk-benefit of routine probiotics in the extremely preterm?
The recent statement from the AAP and a recent review article both state that probiotics only appear to be effective in babies over 1000g birthweight. This would be remarkable if it were true. I am trying to think of another … Continue reading
More thoughts about the “toxicity” of donor milk, a case of Reverse Causation
After my recent post, about the study which suggested that donor milk was killing babies, I have been taking a deeper dive into the article, as I prepare a letter to the editor. Only 2 small subsets of the infants … Continue reading
Posted in Neonatal Research
Tagged breast milk, mortality, Necrotising Enterocolitis, Systematic Reviews
1 Comment
Manipulating the Microbiome
Not with human milk based fortifier, but with probiotics. This post is a sort of intersection between some of my recent posts, human-milk based fortifier does not appear to have a positive effect on the intestinal microbiome. But exogenous probiotics … Continue reading
Interesting study, impossible results. Donor breast milk is not toxic.
Is it possible that giving artificial formula to babies will prevent 90% of the deaths of very preterm babies, compared to using donor human milk? (Chehrazi M, et al. Outcomes in very preterm infants receiving an exclusive human milk diet, … Continue reading
The preterm GI tract is not sterile
The FDA are at it again, they seem to be on a mission to go after suppliers of probiotics for preterm babies, and have now attacked Abbott. They appear to have demanded that they stop marketing their probiotic product, as … Continue reading
Posted in Neonatal Research
Tagged Ethics, mortality, Necrotising Enterocolitis, Probiotics, Regulation, Sepsis
4 Comments
Artificial Formulae and NEC. It is not necessarily the protein source!
As mentioned several times recently, artificial formula seems to lead to an increase in Necrotising Enterocolitis, compared to donor milk. Of note, the trials in the Cochrane Systematic Review include both those with the entire diet being formula or donor … Continue reading
Preventing NEC. Does erythropoietin have a role? Unreliable data.
I wrote a similarly titled post 3 years ago, which lamented the poor research practices of a group in Zhengzhou, who seem to perform large RCTs, then register them after completion, and sometimes register them with different primary outcomes to … Continue reading
Preventing NEC : Gastric acid has a purpose, don’t block it.
As this series of posts have all had something to do with prevention of Necrotising Enterocolitis, I thought I’d write about some recent articles which refer to one of the risk factors for NEC, the use of acid suppression medications. … Continue reading