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Meta
Tag Archives: Necrotising Enterocolitis
World NEC awareness day, part 2
As well as all the high tech mechanistic studies in NEC, such as those that I just posted about, sometimes we need to take a step back and ask some very basic questions. What is the current natural history of … Continue reading
World NEC awareness day.
As we approach world NEC awareness day (May 17th) I thought I’d do a quick PubMed search to see if I’ve missed anything recently, so I started typing “necrotizing” in the search bar, which immediately suggested “necrotizing enterocolitis” as one … Continue reading
Posted in Neonatal Research
Tagged microbiome, Necrotising Enterocolitis, Prebiotics, Probiotics
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AAP guidance on probiotics. As wrong-headed as a head can be wrong.
The AAP issued guidance on probiotic use in the preterm infant last year in the form of what they call a “clinical report”, which I didn’t comment on at the time, I thought it might be a bit redundant as … Continue reading
Survival and outcomes for the extremely preterm. The NICHD network results continue to improve: Can we do even better?
A new publication from the NRN describes short term outcomes and care practices of babies from 22 to 28 weeks gestation born in recent years (2013 to 2018) and for those born in 2013-2016 results of evaluations of those followed … Continue reading
Probiotics in preterms; what’s new? Part 2
Rao S, et al. Probiotic supplementation in neonates with congenital gastrointestinal surgical conditions: a pilot randomised controlled trial. Pediatr Res. 2022. When we started using probiotics there had been a couple of case reports of probiotic associated sepsis in infants … Continue reading
Posted in Neonatal Research
Tagged Necrotising Enterocolitis, Probiotics, Randomized Controlled Trials, Sepsis
3 Comments
Probiotics in preterms; what’s new? Part 1
I haven’t, surprisingly, posted about probiotics recently, but there are some new findings in the literature that warrant discussion. Granger C, et al. Necrotising enterocolitis, late-onset sepsis and mortality after routine probiotic introduction in the UK. Arch Dis Child Fetal … Continue reading
Intestinal perforation in the very preterm, what causes it, and what to do about it.
There are 2 main causes of intestinal perforation in the very preterm, Necrotising Enterocolitis and Spontaneous Perforation. NEC, as I have previously discussed, may be a convenient name for a few different conditions which present in a similar fashion. In … Continue reading
Opioid infusions for ventilated preterm babies
Many practices in neonatology are variable between NICUs, and many vary from year to year; without any good scientific data practices become fashionable or routine or ingrained without necessarily having an evidence base to support them. One such practice is … Continue reading
More about Prebiotics
I don’t know if there is an “official” definition of prebiotics, but I think of them as molecules present in the diet that promote the growth of probiotic organisms. I believe that originally the term was applied only to molecules … Continue reading
Posted in Neonatal Research
Tagged Necrotising Enterocolitis, Prebiotics, Probiotics, Systematic Reviews
2 Comments
Probiotics and NEC, the latest answer?
The updated Cochrane review of probiotics for prevention of NEC, sepsis and mortality has been published. Meta-analysis showed that probiotics may reduce the risk of NEC: RR 0.54, 95% CI 0.45 to 0.65 (54 trials, 10,604 infants; I2 = 17%); … Continue reading
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