Tag Archives: long term outcomes

Longer-term outcomes: what should we measure? part 2

I have made my concerns about developmental screening tests including the Bayley clear over the years, including in the previous post, which might make what I am going to say now seem odd: I do not think we should stop … Continue reading

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Longer term outcomes; what should we measure? part 1.

Many important trials include follow-up to about 2 years in order to ascertain longer-term effects. Such as this one: Adams-Chapman I, et al. Neurodevelopmental outcome of preterm infants enrolled in myo-inositol randomized controlled trial. J Perinatol. 2021. Ira Adams-Chapman was … Continue reading

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When should we transfuse preterm babies, and why? Redux.

The TOP trial has just been published in the FPNEJM (Kirpalani H, et al. Higher or Lower Hemoglobin Transfusion Thresholds for Preterm Infants. N Engl J Med. 2020;383(27):2639-51). It was a multicenter, non-masked RCT among 1800 babies of less than … Continue reading

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Should all asphyxiated babies have MR spectroscopy?

MRI post-asphyxia, and post-rewarming, seems to be more predictive of long term outcomes than MRI at term for preterm infants. Imaging and analysis of the Apparent Diffusion Coefficient in the PLIC (posterior Limb of the Internal Capsule), for example, has … Continue reading

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Do Sub-Ependymal Haemorrhages cause cerebral palsy?

The germinal matrix is a region in the immature brain where a large proportion of cortical neurones are formed before they migrate out to form the neo-cortex. It is intensely metabolically active as it is producing hundreds of thousands of … Continue reading

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Does intravitreal bevacizumab adversely affect long term development? Two simultaneous systematic reviews say yes, or no.

A reliable answer to the above question would require a large multicentre RCT comparing intravitreal bevacizumab (IVB) to laser, powered for long term outcomes. Such a trial does not currently exist. As a result, 2 groups have just published systematic … Continue reading

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Three trials with null results, how should we respond?

These 3 articles have just been published, all show no difference in long term outcomes between the randomized groups. What does that mean for the impact on therapeutic decision-making? Natalucci G, et al. Neurodevelopmental Outcomes at Age 5 Years After … Continue reading

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Quality of life cannot be predicted from a brain scan

…either ultrasound or MRI, or by EEG, or neurological examination, or even during follow-up by screening for disabilities. That title is from a recently published editorial (Fayed N, et al. Quality of life cannot be predicted from a brain scan. … Continue reading

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What happened to the HeROs?

I had to find a way of changing HeRO to Heroes as an excuse for posting a link to this video But also the results of a long term follow up of the HeRO trial have been published. The original … Continue reading

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Does LISA protect your brain?

A few years ago now a multicenter RCT among infants of 23 to 26 weeks gestation showed that LISA was possible in even these most immature infants., NINSAPP. Kribs A, et al. Nonintubated Surfactant Application vs Conventional Therapy in Extremely … Continue reading

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