Monthly Archives: October 2014

What do parents of twins (and the twins) think about randomizing multiples

Posted on 31 October 2014 by Keith Barrington

There has been some controversy recently about how we should randomize twins (and triplets or more) in neonatal trials. The question being whether randomizing the babies independently or randomizing them as a group is preferable. Those who wish to randomize … Continue reading →

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Reassuring Prophylactic Indomethacin Data

Posted on 28 October 2014 by Keith Barrington

One of Annie Janvier’s first research projects was a case control study of the influence of prophylactic indomethacin on intestinal perforations. Under my supervision she analyzed cases of spontaneous intestinal perforation (SIP), and we analyzed the influence of prophylactic indomethacin, … Continue reading →

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Effects of (not very) NICE guidelines

Posted on 27 October 2014 by Keith Barrington

Call me prescient, OK, you won’t, but I will. Two recent observational studies suggest that the recent NICE guidelines have had adverse effects on infants evaluated for potential early neonatal sepsis. ‘NICE’ of course is not an adjective for how good … Continue reading →

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Responses to letters regarding our Journal of Pediatrics Probiotics article

Posted on 26 October 2014 by Keith Barrington

Here are my answers to 2 letters written regarding the article that Annie Janvier, Josianne Malo and I wrote about the impact of probiotics in our NICU. I just realized that Elsevier’s rules allow me under the ‘permitted scholarly posting’ … Continue reading →

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Ventilating babies during resuscitation

Posted on 15 October 2014 by Keith Barrington

Three recent-(ish) articles examining how we should ventilate babies and monitor what we are doing. Milner A, Murthy V, Bhat P, Fox G, Campbell ME, Milner AD, et al. Evaluation of respiratory function monitoring at the resuscitation of prematurely born … Continue reading →

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Now Cross-Posting to 99NICU.org

Posted on 15 October 2014 by Keith Barrington

Stefan Johansson, who runs the NICU website/community 99NICU.org asked if I would be interested in cross-posting my Neonatal Research posts in the blog section of their website. I will post most of my musings over at their website as well, … Continue reading →

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Appropriate outcomes for neonatal research

Posted on 14 October 2014 by Keith Barrington

Neil Marlow has published a thoughtful, and thought provoking, article to address the issue outlined in the title. What are the appropriate outcomes when designing neonatal research studies? It has become almost a rule, that a multi-center trial of an … Continue reading →

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Upcoming Webinar

Posted on 9 October 2014 by Keith Barrington

If you are on their mailing list you will have received the following notice: Keith Barrington Oct. 22 Register today for our 2014-2015 Children’s Mercy Bioethics Center webinar series. The focus this year is “Ethical Issues in Pediatric Clinical Research.” … Continue reading →

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Probiotics prevent NEC in rats too!

Posted on 8 October 2014 by Keith Barrington

Mark Underwood has been very active in the investigations of probiotics and their effects on the neonatal bowel. His new publication is a fascinating exploration of what happens in a rat model of NEC when they receive bifidobacterium infantis, also … Continue reading →

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The voice of Parents, now in print.

Posted on 8 October 2014 by Keith Barrington

Katharina Staub and other parents have written and published an article in Acta Paediatrica. ‘ Our child is not just a gestational age‘. In the NICU babies are often referred to by how many weeks they spent in the uterus, … Continue reading →

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