Tag Archives: Sepsis

Recent publications

Even though the blog has been quiet recently, other academic output has continued… In the NICU we are often faced with babies with late- or early- onset sepsis. The worst cases develop shock, which carries a significant mortality; they may … Continue reading

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Antibiotics are dangerous, unless you actually need them.

In response to my previous post Claus Klingenberg wrote a comment in which he mentioned a recent systematic review that he had published with a group of colleagues. This review of a small number of RCTs (9) and a larger … Continue reading

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A negative view of culture-negative sepsis

I have now posted quite a few times about ways to reduce antibiotic use in the NICU, and in the term baby nursery. One thing that would help to reduce unnecessary usage is to abandon the idea that culture-negative sepsis … Continue reading

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Using less antibiotics

Most newborns who receive antibiotics are not infected. This is true of full term babies in normal newborn care, and preterms in the NICU. For most infants antibiotics can be stopped after 36 hours if cultures are negative at that … Continue reading

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Short courses of Steroids are hazardous… even for adults!

There were a number of things that surprised me in this study. the first was how many adults get short courses of oral steroids in the USA (and for all I know in other countries too). Waljee AK, et al. … Continue reading

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Early low dose hydrocortisone seems to not affect medium term development; PREMILOC outcomes at 22 months.

The PREMILOC trial was a multi-center RCT of hydrocortisone, 0.5mg/kg twice per day for 7 days followed by 0.5 mg/kg per day for 3 days, given starting within 24 hours of age to infants of 24 to less than 28 … Continue reading

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Reducing antibiotic use in full term babies.

Early onset neonatal sepsis currently has an incidence in North America among term infants of about 0.5 to 1 per thousand live births. But 15% of newborn infants have risk factors and they end up receiving antibiotics if current guidelines … Continue reading

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