Tag Archives: Sepsis

Early low dose hydrocortisone seems to not affect medium term development; PREMILOC outcomes at 22 months.

The PREMILOC trial was a multi-center RCT of hydrocortisone, 0.5mg/kg twice per day for 7 days followed by 0.5 mg/kg per day for 3 days, given starting within 24 hours of age to infants of 24 to less than 28 … Continue reading

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Reducing antibiotic use in full term babies.

Early onset neonatal sepsis currently has an incidence in North America among term infants of about 0.5 to 1 per thousand live births. But 15% of newborn infants have risk factors and they end up receiving antibiotics if current guidelines … Continue reading

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Neonatal Sepsis after Chorioamnionitis, what to do about healthy appearing newborns

In 2007, when I was chair of the CPS Fetus and Newborn Committee, we published a guideline regarding the approach to term and late preterm infants with perinatal risk factors for sepsis. Obviously any infant with clinical signs consistent with … Continue reading

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Culture negative sepsis: what is it?

One of the things that I have wondered about over the years is whether infants who appear to be infected, but who have negative cultures, might have viral infections. A new study suggests that this is not rare. Kidszun A, et … Continue reading

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The microbiome of plastic tubes in children

Petersen SM, et al. Nasogastric feeding tubes from a neonatal department yield high concentrations of potentially pathogenic bacteria – even one day after insertion. Pediatr Res. 2016.  These authors cultured 94 nasogastric feeding tubes from 34 preterm infants. 1 ml … Continue reading

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Is breast-milk really best?

Although many people (including myself) are convinced that human breast milk is the preferable nutrition for human babies, including the preterm, some of the evidence regarding benefits is shaky. For example the evidence that breast milk feeding reduces late-onset sepsis. … Continue reading

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TPN toxic?

Humans, after they are born, are supposed to receive their nutrition via the gut. Before that of course, they receive a continuous infusion of nutrition via the umbilical vein. We are far from having an intravenous nutrition mixture for sick … Continue reading

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