Tag Archives: Sepsis

What happened to the HeROs?

I had to find a way of changing HeRO to Heroes as an excuse for posting a link to this video But also the results of a long term follow up of the HeRO trial have been published. The original … Continue reading

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CRP can suggest that babies are not infected, when you already know!

I wrote a blog post about 3 years ago about a study examining procalcitonin use in neonatal early-onset sepsis. You can see from my post that the authors didn’t, to my mind, show any utility of procalcitonin (PCT) either alone … Continue reading

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Lactoferrin: Does it decrease late-onset sepsis?

The first multicentre trial of bovine lactoferrin supplementation in preterm infants showed a dramatic reduction in late-onset sepsis of about 70%. I was very excited when I first saw Paolo Manzoni’s trial and rushed to set up a pilot in … Continue reading

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Screening for early-onset neonatal sepsis in the UK. NICE or not?

Evaluating a screening procedure for a rare serious phenomenon, such as early-onset neonatal sepsis, is tricky. A perfect screening process would catch all of the cases that require treating at an early stage and would be completely specific, thus eliminating … Continue reading

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Linezolid seems safe for preterms, probably

A few years ago we started having difficulty clearing Coagulase-Negative Staphylococcal (CoNS) sepsis from the blood cultures of some babies in our NICU, children with CoNS also seemed to be sicker, and to more often have thrombocytopenia. It was at … Continue reading

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They really are CRAP! C-ReActive Protein: “Hazardous Waste”.

I have railed against the use of C-Reactive Protein, CRP, on this blog previously, it was my analysis that the CRP is sensitive, but with very poor specificity, both for early-onset sepsis, and for late-onset sepsis. A new systematic review … Continue reading

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Where does sepsis come from?

One of the findings of the recent SIFT trial was that although the babies in the fast feeding group had shorter duration of parenteral nutrition, TPN, (and presumably of central lines), they did not have less late-onset sepsis, LOS. Why … Continue reading

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RCTs prevail: Antibiotic impregnation of central lines doesn’t reduce sepsis.

In older children and adults who need central venous access, using catheters impregnated with stuff that kills bugs decreases invasive sepsis rates. A multicentre trial in English PICUs showed a reduction in sepsis from 4% to 1% when antibiotic impregnated … Continue reading

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Clinical evaluation vs Technology

Two recent trials in adult ICU patients ask very interesting questions, questions which are only linked by testing something clinically simple versus a more technologically demanding evaluation. The first was comparing the use of serum lactate concentrations versus capillary filling … Continue reading

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Prebiotics and preterms and probiotics.

A selection of recent publications, regarding the issues in the title, that I find interesting and which seem to tell a consistent story. From Nick Embleton’s group the following interesting study (Stewart CJ, et al. Longitudinal development of the gut … Continue reading

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