Tag Archives: antibiotics

It’s Raining Antibiotics

Posted on 8 November 2022 by Keith Barrington

Early onset sepsis is a serious condition with a substantial morbidity, and, thankfully, a relatively low mortality in recent years. Prompt recognition and early treatment are essential, but early clinical signs and risk factors tend to be non-specific. As a … Continue reading →

Posted in Neonatal Research | Tagged , , , | 3 Comments

More musings on the microbiome

Posted on 21 January 2022 by Keith Barrington

We are fortunate in neonatology to not have to worry about C difficile, partly because the name has been changed for this germ as well (now Clostridioides, rather than Clostridium), and it is one less name change to keep up … Continue reading →

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Linezolid seems safe for preterms, probably

Posted on 5 March 2020 by Keith Barrington

A few years ago we started having difficulty clearing Coagulase-Negative Staphylococcal (CoNS) sepsis from the blood cultures of some babies in our NICU, children with CoNS also seemed to be sicker, and to more often have thrombocytopenia. It was at … Continue reading →

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Antibiotics are dangerous, unless you actually need them.

Posted on 3 October 2017 by Keith Barrington

In response to my previous post Claus Klingenberg wrote a comment in which he mentioned a recent systematic review that he had published with a group of colleagues. This review of a small number of RCTs (9) and a larger … Continue reading →

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A negative view of culture-negative sepsis

Posted on 27 September 2017 by Keith Barrington

I have now posted quite a few times about ways to reduce antibiotic use in the NICU, and in the term baby nursery. One thing that would help to reduce unnecessary usage is to abandon the idea that culture-negative sepsis … Continue reading →

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Using less antibiotics

Posted on 14 August 2017 by Keith Barrington

Most newborns who receive antibiotics are not infected. This is true of full term babies in normal newborn care, and preterms in the NICU. For most infants antibiotics can be stopped after 36 hours if cultures are negative at that … Continue reading →

Posted in Neonatal Research | Tagged , | 3 Comments