Tag Archives: steroids

Inhaled steroids for BPD?

In a recent post I promoted a new Barrington rule for meta-analysis (it probably already existed somewhere but I am claiming priority anyway, it’s a “post-truth” kind of thing). The rule was that in a systematic review you shouldn’t pool … Continue reading

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Antenatal Steroids closer to term?

A new systematic review in the BMJ (Saccone G, Berghella V. Antenatal corticosteroids for maturity of term or near term fetuses: systematic review and meta-analysis of randomized controlled trials. BMJ. 2016;355:i5044) includes 3 studies which examined the use of antenatal … Continue reading

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Inhaled steroids to prevent BPD, another trial.

This time from Japan, Nakamura T, et al. Early inhaled steroid use in extremely low birthweight infants: a randomised controlled trial. Archives of Disease in Childhood – Fetal and Neonatal Edition. 2016. 211 babies with a birth weight less than 1000 … Continue reading

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Early low dose systemic hydrocortisone to prevent death or chronic lung disease? Hold on a bit.

An important high quality trial has just been published, it has taken me a bit longer than usual to process the new info. Among other reasons a nice review was posted on the “other neonatal blog“, but I wanted to … Continue reading

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Steroids directly in the lungs? Version 2

A couple of weeks ago I discussed a new multicenter RCT which examined the effects of multiple repeated doses of steroids, given by inhalation starting on the first day of life, and continuing, at least until the infants reached 14 … Continue reading

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Antenatal Steroids at 36 weeks?

Most of the studies of antenatal steroids for lung maturation included mothers at less than 34 weeks. Most babies at 34 to 36 weeks do fine, although there is a growing realization of their increased long term risks. Even the … Continue reading

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Early steroids to prevent Chronic Lung Disease; give them directly into the lungs?

Bassler D, et al. Early Inhaled Budesonide for the Prevention of Bronchopulmonary Dysplasia. New England Journal of Medicine. 2015;373(16):1497-506. One of those ongoing trials that we have been awaiting the results of has just been published. The NEUROSIS trial was a … Continue reading

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