Tag Archives: asphyxia

Teaching clinicians to evaluate encephalopathy

I hope this link stays active for ever as it is a great resource… Courtney Wusthoff from Stanford has developed a web-based educational tool, designed initially, I think, for medical (pediatric) residents. Their team has evaluated whether or not this … Continue reading

Posted in Neonatal Research | Tagged | 3 Comments

Sustained inflation during neonatal resuscitation? Not so fast…

A sustained inflation at birth of an asphyxiated lamb which lasts 30 seconds leads to much more rapid restoration of heart rate and blood pressure than either conventional ventilation or a series of shorter sustained inflations of 5 seconds each. … Continue reading

Posted in Neonatal Research | Tagged , , | 1 Comment

Neonatal Updates

Raina A, et al. Treating perinatal asphyxia with theophylline at birth helps to reduce the severity of renal dysfunction in term neonates. Acta Paediatrica. 2016. This was an RCT in 160 full-term babies with perinatal asphyxia and encephalopathy. Babies, who … Continue reading

Posted in Neonatal Research | Tagged , | Leave a comment

Erythropoietin for Asphyxia

A preliminary RCT in babies undergoing therapeutic hypothermia (Wu YW, et al. High-dose Erythropoietin and Hypothermia for Hypoxic-Ischemic Encephalopathy: A Phase II Trial. Pediatrics. 2016). They randomized 50 babies with HIE who were being cooled to 1000 units/kg on days 1,2,3,5, … Continue reading

Posted in Neonatal Research | Tagged , , | Leave a comment

The death knell for Xenon?

Azzopardi D, et al. Moderate hypothermia within 6 h of birth plus inhaled xenon versus moderate hypothermia alone after birth asphyxia (TOBY-Xe): a proof-of-concept, open-label, randomised controlled trial. The Lancet Neurology. 2016;15(2):145-53.  Babies who undergo therapeutic hypothermia for perinatal encephalopathy … Continue reading

Posted in Neonatal Research | Tagged , | 4 Comments

Treating seizures: bumetanide doesn’t seem to work

One of the many frustrating things in neonatology is the treatment of convulsions. As Gerry Boylan and Ronit Pressler wrote in the introductory section of the excellent issue of Seminars in Fetal and Neonatal Medicine which was all about neonatal seizures, … Continue reading

Posted in Neonatal Research | Tagged , | Leave a comment

How long is too long?

When a baby is unexpectedly born without a heart beat, and resuscitation is initiated, the outcome may be a failed resuscitation. Even if everything is done correctly. If you are doing everything correctly, and the baby doesn’t respond right away, … Continue reading

Posted in Neonatal Research | Tagged , , , | 1 Comment