Tag Archives: asphyxia

Neonatal Updates

Raina A, et al. Treating perinatal asphyxia with theophylline at birth helps to reduce the severity of renal dysfunction in term neonates. Acta Paediatrica. 2016. This was an RCT in 160 full-term babies with perinatal asphyxia and encephalopathy. Babies, who … Continue reading

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Erythropoietin for Asphyxia

A preliminary RCT in babies undergoing therapeutic hypothermia (Wu YW, et al. High-dose Erythropoietin and Hypothermia for Hypoxic-Ischemic Encephalopathy: A Phase II Trial. Pediatrics. 2016). They randomized 50 babies with HIE who were being cooled to 1000 units/kg on days 1,2,3,5, … Continue reading

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The death knell for Xenon?

Azzopardi D, et al. Moderate hypothermia within 6 h of birth plus inhaled xenon versus moderate hypothermia alone after birth asphyxia (TOBY-Xe): a proof-of-concept, open-label, randomised controlled trial. The Lancet Neurology. 2016;15(2):145-53.  Babies who undergo therapeutic hypothermia for perinatal encephalopathy … Continue reading

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Treating seizures: bumetanide doesn’t seem to work

One of the many frustrating things in neonatology is the treatment of convulsions. As Gerry Boylan and Ronit Pressler wrote in the introductory section of the excellent issue of Seminars in Fetal and Neonatal Medicine which was all about neonatal seizures, … Continue reading

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How long is too long?

When a baby is unexpectedly born without a heart beat, and resuscitation is initiated, the outcome may be a failed resuscitation. Even if everything is done correctly. If you are doing everything correctly, and the baby doesn’t respond right away, … Continue reading

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Neonatal Updates

There’s been a lot of good stuff published recently, so time for a couple of Neonatal Updates. First the most recent (May) issue of the Archives Fetal and Neonatal edition was packed with interesting publications.(including 2 I have already blogged … Continue reading

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Timing of MRI after HIE

Three recent articles have investigated whether we should wait until a week or so after birth to perform brain imaging in infants with encephalopathy, or whether earlier imaging might be just as predictive. The three articles have consistent findings, which is … Continue reading

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