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Tag Archives: Retinopathy of Prematurity
Insulin like growth factor: does it prevent BPD, or does it increase RoP and mortality?
In the March print edition of the Journal of Pediatrics, the report of the Insulin-like growth factor 1/IGF binding protein 3 trial, as a preventive for retinopathy. Ley D, et al. rhIGF-1/rhIGFBP-3 in Preterm Infants: A Phase 2 Randomized Controlled … Continue reading
Posted in Neonatal Research
Tagged BPD, IGF-1, Randomized Controlled Trials, Retinopathy of Prematurity
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PAS 2018 No5: the trial with no name… propranolol for early RoP, a proper trial.
As far as I can see, this trial has no acronym, which isn’t a big deal, but it also doesn’t show up on trial registry searches, which is a big deal. Trials must be registered before starting them, it ensures … Continue reading
Posted in Neonatal Research
Tagged Randomized Controlled Trials, Retinopathy of Prematurity
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Does erythropoietin improve preterm babies development?
Ohls RK, et al. Preschool Assessment of Preterm Infants Treated With Darbepoetin and Erythropoietin. Pediatrics. 2016;137(3):1-9. Robin Ohls has been working on Erythropoietin, and its longer acting analogue darbepoietin, for many years now. As well as demonstrating that it stimulates … Continue reading
Retinopathy: up or down?
The oxygen saturation targeting trials showed more retinopathy with higher oxygen saturation targets. Will this translate into more retinopathy in actual practice? Many units have increased their saturation targets as a result of those studies. This may indeed lead to … Continue reading
Neonatal Updates
Gschließer A, et al. Inter-expert and Intra-expert Agreement on the Diagnosis and Treatment of Retinopathy of Prematurity. American Journal of Ophthalmology. 2015;160(3):553-60.e3. The investigators showed 52 retinal photographs to 7 expert ophthalmologists, and then 8 weeks later showed them to … Continue reading
NICUs are working better: still room for improvement.
As NICUs have become more effective, any proportional incremental improvements will necessarily get smaller, so larger and larger datasets will be needed to show any trends. The NICHD has just published data about survival and major acute morbidities among extremely … Continue reading
Posted in Neonatal Research
Tagged BPD, mortality, Necrotising Enterocolitis, Retinopathy of Prematurity, Sepsis
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Oxygen is good for you
Of course you can have too much of a good thing, but you should also try and stay above the minimum. The COT trial investigators, led by Christian Poets, have published a secondary analysis of the results, examining in particular … Continue reading
Posted in Neonatal Research
Tagged Apnea, Hypoxia, long term outcomes, oxygen toxicity, Retinopathy of Prematurity
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