Tag Archives: Retinopathy of Prematurity

Anti VEGF treatment of retinopathy: and the long term?

Posted on 9 August 2022 by Keith Barrington

There remains some doubt about the impacts on cerebral development, and thus on developmental progress of anti-VEGF treated babies. It is possible that there are cerebral effects of VEGF inhibition (or interception) and it isn’t clear what the exposure of … Continue reading →

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Anti-VEGF vs laser therapy for retinopathy, not worse, but not not worse?

Posted on 3 August 2022 by Keith Barrington

A newer anti-VEGF drug has been invented, and evaluated in retinopathy therapy. This new drug aflibercept works differently to the “-mab” drugs we have been using. Those others are monoclonal antibodies (hence mab) directed against VEGF, whereas this new stuff … Continue reading →

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Automated oxygen control, what’s taking so long?

Posted on 29 April 2022 by Keith Barrington

A long long time ago, in a galaxy… actually quite near here, the idea of servo control of inspired oxygen was already in the air. At the time I first heard about it, the idea was to control FiO2 based … Continue reading →

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Does intravitreal bevacizumab adversely affect long term development? Two simultaneous systematic reviews say yes, or no.

Posted on 14 December 2020 by Keith Barrington

A reliable answer to the above question would require a large multicentre RCT comparing intravitreal bevacizumab (IVB) to laser, powered for long term outcomes. Such a trial does not currently exist. As a result, 2 groups have just published systematic … Continue reading →

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International variations in outcomes of extreme preterm infants

Posted on 9 December 2019 by Keith Barrington

A publication from an international collaboration of neonatal databases has just appeared, (Lui K, et al. Trends in Outcomes for Neonates Born Very Preterm and Very Low Birth Weight in 11 High-Income Countries. J Pediatr. 2019). It makes very interesting … Continue reading →

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Eye exams for fewer babies

Posted on 17 October 2019 by Keith Barrington

In Canada, the current Canadian Pediatric Society recommendations, dating from 2016 are to screen infants for retinopathy of prematurity with Gestational Age <31 weeks or Birth weight <1,251 g. These recommendations are already somewhat more restrictive than other countries, in … Continue reading →

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Insulin like growth factor: does it prevent BPD, or does it increase RoP and mortality?

Posted on 1 May 2019 by Keith Barrington

In the March print edition of the Journal of Pediatrics, the report of the Insulin-like growth factor 1/IGF binding protein 3 trial, as a preventive for retinopathy. Ley D, et al. rhIGF-1/rhIGFBP-3 in Preterm Infants: A Phase 2 Randomized Controlled … Continue reading →

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PAS 2018 No5: the trial with no name… propranolol for early RoP, a proper trial.

Posted on 11 May 2018 by Keith Barrington

As far as I can see, this trial has no acronym, which isn’t a big deal, but it also doesn’t show up on trial registry searches, which is a big deal. Trials must be registered before starting them, it ensures … Continue reading →

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Does erythropoietin improve preterm babies development?

Posted on 15 March 2016 by Keith Barrington

Ohls RK, et al. Preschool Assessment of Preterm Infants Treated With Darbepoetin and Erythropoietin. Pediatrics. 2016;137(3):1-9. Robin Ohls has been working on Erythropoietin, and its longer acting analogue darbepoietin, for many years now. As well as demonstrating that it stimulates … Continue reading →

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Retinopathy: up or down?

Posted on 17 November 2015 by Keith Barrington

The oxygen saturation targeting trials showed more retinopathy with higher oxygen saturation targets. Will this translate into more retinopathy in actual practice? Many units have increased their saturation targets as a result of those studies. This may indeed lead to … Continue reading →

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