Tag Archives: Retinopathy of Prematurity

Does intravitreal bevacizumab adversely affect long term development? Two simultaneous systematic reviews say yes, or no.

Posted on 14 December 2020 by keithbarrington

A reliable answer to the above question would require a large multicentre RCT comparing intravitreal bevacizumab (IVB) to laser, powered for long term outcomes. Such a trial does not currently exist. As a result, 2 groups have just published systematic … Continue reading →

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International variations in outcomes of extreme preterm infants

Posted on 9 December 2019 by keithbarrington

A publication from an international collaboration of neonatal databases has just appeared, (Lui K, et al. Trends in Outcomes for Neonates Born Very Preterm and Very Low Birth Weight in 11 High-Income Countries. J Pediatr. 2019). It makes very interesting … Continue reading →

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Eye exams for fewer babies

Posted on 17 October 2019 by keithbarrington

In Canada, the current Canadian Pediatric Society recommendations, dating from 2016 are to screen infants for retinopathy of prematurity with Gestational Age <31 weeks or Birth weight <1,251 g. These recommendations are already somewhat more restrictive than other countries, in … Continue reading →

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Insulin like growth factor: does it prevent BPD, or does it increase RoP and mortality?

Posted on 1 May 2019 by keithbarrington

In the March print edition of the Journal of Pediatrics, the report of the Insulin-like growth factor 1/IGF binding protein 3 trial, as a preventive for retinopathy. Ley D, et al. rhIGF-1/rhIGFBP-3 in Preterm Infants: A Phase 2 Randomized Controlled … Continue reading →

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PAS 2018 No5: the trial with no name… propranolol for early RoP, a proper trial.

Posted on 11 May 2018 by keithbarrington

As far as I can see, this trial has no acronym, which isn’t a big deal, but it also doesn’t show up on trial registry searches, which is a big deal. Trials must be registered before starting them, it ensures … Continue reading →

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Does erythropoietin improve preterm babies development?

Posted on 15 March 2016 by keithbarrington

Ohls RK, et al. Preschool Assessment of Preterm Infants Treated With Darbepoetin and Erythropoietin. Pediatrics. 2016;137(3):1-9. Robin Ohls has been working on Erythropoietin, and its longer acting analogue darbepoietin, for many years now. As well as demonstrating that it stimulates … Continue reading →

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Retinopathy: up or down?

Posted on 17 November 2015 by keithbarrington

The oxygen saturation targeting trials showed more retinopathy with higher oxygen saturation targets. Will this translate into more retinopathy in actual practice? Many units have increased their saturation targets as a result of those studies. This may indeed lead to … Continue reading →

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Neonatal Updates

Posted on 17 November 2015 by keithbarrington

Gschließer A, et al. Inter-expert and Intra-expert Agreement on the Diagnosis and Treatment of Retinopathy of Prematurity. American Journal of Ophthalmology. 2015;160(3):553-60.e3. The investigators showed 52 retinal photographs to 7 expert ophthalmologists, and then 8 weeks later showed them to … Continue reading →

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NICUs are working better: still room for improvement.

Posted on 11 September 2015 by keithbarrington

As NICUs have become more effective, any proportional incremental improvements will necessarily get smaller, so larger and larger datasets will be needed to show any trends. The NICHD has just published data about survival and major acute morbidities among extremely … Continue reading →

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Oxygen is good for you

Posted on 28 August 2015 by keithbarrington

Of course you can have too much of a good thing, but you should also try and stay above the minimum. The COT trial investigators, led by Christian Poets, have published a secondary analysis of the results, examining in particular … Continue reading →

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