Tag Archives: Retinopathy of Prematurity

Neonatal Updates

Posted on 17 November 2015 by Keith Barrington

Gschließer A, et al. Inter-expert and Intra-expert Agreement on the Diagnosis and Treatment of Retinopathy of Prematurity. American Journal of Ophthalmology. 2015;160(3):553-60.e3. The investigators showed 52 retinal photographs to 7 expert ophthalmologists, and then 8 weeks later showed them to … Continue reading →

Posted in Neonatal Research | Tagged , | Leave a comment

NICUs are working better: still room for improvement.

Posted on 11 September 2015 by Keith Barrington

As NICUs have become more effective, any proportional incremental improvements will necessarily get smaller, so larger and larger datasets will be needed to show any trends. The NICHD has just published data about survival and major acute morbidities among extremely … Continue reading →

Posted in Neonatal Research | Tagged , , , , | Leave a comment

Oxygen is good for you

Posted on 28 August 2015 by Keith Barrington

Of course you can have too much of a good thing, but you should also try and stay above the minimum. The COT trial investigators, led by Christian Poets, have published a secondary analysis of the results, examining in particular … Continue reading →

Posted in Neonatal Research | Tagged , , , , | Leave a comment

Bevacizumab or that other more expensive one?

Posted on 2 April 2015 by Keith Barrington

A very interesting and depressing group of articles in today’s BMJ. Retinopathy of prematurity is a small market compared to wet macular degeneration in the elderly, in whom VEGF inhibitors are proven to be extremely effective. Ranibizumab (I will call … Continue reading →

Posted in Neonatal Research | Tagged | 1 Comment

Should we be using bevacizumab for retinopathy of prematurity?

Posted on 26 March 2015 by Keith Barrington

 Geloneck MM, Cet al: Refractive outcomes following bevacizumab monotherapy compared with conventional laser treatment: a randomized clinical trial. JAMA Ophthalmol 2014, 132(11):1327-1333. In this follow-up of the BEAT-RoP trial, eyes randomized to have laser were more likely to have severe … Continue reading →

Posted in Neonatal Research | Tagged , | 2 Comments

Poietins for the brain?

Posted on 14 May 2014 by Keith Barrington

Ohls RK, Kamath-Rayne BD, Christensen RD, Wiedmeier SE, Rosenberg A, Fuller J, et al. Cognitive Outcomes of Preterm Infants Randomized to Darbepoetin, Erythropoietin, or Placebo. Pediatrics. 2014. I’ve written about this trial before, a smallish 3 arm trial of erythropoietin, … Continue reading →

Posted in Neonatal Research | Tagged , , | Leave a comment

Oxygen, transfusions, and NEC

Posted on 31 March 2014 by Keith Barrington

What causes NEC! The answer is ‘who knows?’, or perhaps a better one would be ‘its complicated…’ You probably need an immature gut, gut mucosal injury, inflammation and cytokine release, and an abnormal microbiome, all of which probably interact in … Continue reading →

Posted in Neonatal Research | Tagged , , , , , | Leave a comment

Public citizen are becoming a public danger

Posted on 13 March 2014 by Keith Barrington

Public citizen are at it again, they have written another letter to the director of the DHHSS to try and follow up on their previous nonsense. I didn’t write about this when I first heard about it, as 1. it … Continue reading →

Posted in Neonatal Research | Tagged , , , , | Leave a comment

Insulin, nutrition, insulin-like growth factors and the retina

Posted on 13 March 2014 by Keith Barrington

I’d really like to see a good quality review article with that title, there are several that touch on these issues (for example, here and here), but I find the data hard to digest, probably because it is relatively novel … Continue reading →

Posted in Neonatal Research | Tagged , | Leave a comment

Omega 3 containing lipid emulsions for the preterm: time for a large RCT

Posted on 11 December 2013 by Keith Barrington

A recent small RCT from Turkey, n=80 (Beken S, Dilli D, Fettah ND, Kabatas EU, Zenciroglu A, Okumus N: The influence of fish-oil lipid emulsions on retinopathy of prematurity in very low birth weight infants: A randomized controlled trial. Early … Continue reading →

Posted in Neonatal Research | Tagged , , | Leave a comment