Tag Archives: BPD

Omega-3 fatty acids, hype, and hope, and disappointment.

Omega-3 fatty acids seem to be important for many functions, and currently many babies, especially preterm babies appear to be deficient compared to babies born at term. There has been much research into these dietary components, and they certainly are … Continue reading

Posted in Neonatal Research | Tagged , , , | Leave a comment

What to do about early postnatal steroids?

Steroid metabolism in the very immature infant is… immature. Adrenal function is still developing in the fetus between 20 and 26 weeks, and a source of precursors from the placenta is important, but obviously disappears at delivery. Very preterm babies … Continue reading

Posted in Neonatal Research | Tagged , , , , | 2 Comments

What respiratory outcomes are important?

When bronchopulmonary dysplasia was first described by Northway in 1967 he didn’t try to produce a definition, his paper was a description of a small number of preterm survivors of high oxygen and positive pressure ventilation. He noted some years … Continue reading

Posted in Neonatal Research | Tagged , , , | 1 Comment

Just do it! Who should go home on oxygen?

A new guideline from the ATS has been published, which gives guidelines for home oxygen therapy for children, one large group of which is, of course, babies with bronchopulmonmary dysplasia. Hayes D, Jr., et al. Home Oxygen Therapy for Children. … Continue reading

Posted in Neonatal Research | Tagged , , , | 2 Comments

Putting steroids in the lungs? Still unclear if it is safe or effective.

Systematic reviews, and meta-analyses should help us make a clinical decision, by accumulating all the evidence, determining its quality, and synthesizing impacts, we can then decide which therapeutic option to pursue. This latest review answers the following question “should I … Continue reading

Posted in Neonatal Research | Tagged , , | Leave a comment

Insulin like growth factor: does it prevent BPD, or does it increase RoP and mortality?

In the March print edition of the Journal of Pediatrics, the report of the Insulin-like growth factor 1/IGF binding protein 3 trial, as a preventive for retinopathy. Ley D, et al. rhIGF-1/rhIGFBP-3 in Preterm Infants: A Phase 2 Randomized Controlled … Continue reading

Posted in Neonatal Research | Tagged , , , | Leave a comment

At last, something men are better at than women!

That is, giving blood for babies, at least maybe. The introduction to this new publication notes something that I was not aware of, that plasma donated by women is associated with a substantially greater frequency of transfusion related complications than … Continue reading

Posted in Neonatal Research | Tagged , | 1 Comment

PAS 2018 No2: let’s STOP-BPD

The STOP-BPD trial was a multicenter trial from Holland, (registered as NTR2768) over 180 babies were randomized to each arm of this trial, they were <30 weeks or less than 1250 g at birth, and were still ventilated at 2 … Continue reading

Posted in Neonatal Research | Tagged , , | Leave a comment

Inhaled Steroids to Prevent BPD? Think again… again!

The NEUROSIS trial that I discussed in my previous post has, among other published trials, most in common with the trial by Nakamura published in 2016. Nakamura T, et al. Early inhaled steroid use in extremely low birthweight infants: a … Continue reading

Posted in Neonatal Research | Tagged , , , , | Leave a comment

Early low dose hydrocortisone seems to not affect medium term development; PREMILOC outcomes at 22 months.

The PREMILOC trial was a multi-center RCT of hydrocortisone, 0.5mg/kg twice per day for 7 days followed by 0.5 mg/kg per day for 3 days, given starting within 24 hours of age to infants of 24 to less than 28 … Continue reading

Posted in Neonatal Research | Tagged , , , , | Leave a comment