Tag Archives: Hemodynamics

Does acidosis affect contractility of the neonatal heart? And does bicarbonate help?

Posted on 27 January 2020 by Keith Barrington

I sometimes write posts which are not based on a new publication but to address a clinical issue that I think is important, and may not be clear to everyone. Often triggered by something that has happened in my own … Continue reading →

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Recent publications

Posted on 16 November 2017 by Keith Barrington

Even though the blog has been quiet recently, other academic output has continued… In the NICU we are often faced with babies with late- or early- onset sepsis. The worst cases develop shock, which carries a significant mortality; they may … Continue reading →

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Causes and Consequences of Bronchopulmonary Dysplasia

Posted on 21 June 2016 by Keith Barrington

Sullivan K, et al. The Association between Positive Tracheal Aspirate Cultures and Adverse Pulmonary Outcomes in Preterm Infants with Severe Bronchopulmonary Dysplasia. American journal of perinatology. 2016(EFirst).  This is an interesting study, with many limitations. 121 intubated VLBW preterm infants … Continue reading →

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Under Pressure….

Posted on 26 August 2015 by Keith Barrington

Colm O’Donnell once wrote an article with a whole line from a David Bowie song embedded in the article’s title (O’Donnell CPF. Turn and face the strange – ch..ch..ch..changes to neonatal resuscitation guidelines in the past decade. Journal of Paediatrics … Continue reading →

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Cord milking/delayed clamping at the 2015 PAS-meeting

Posted on 19 May 2015 by Keith Barrington

I have tried to go through the abstracts from PAS to find those that had new information, from controlled trials, about the efficacy and safety of cord milking and/or delayed clamping. Mercer and the group from Rhode Island presented the … Continue reading →

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Low Cardiac Output after PDA ligation

Posted on 22 May 2014 by Keith Barrington

Some babies after PDA ligation develop a low cardiac output, Patrick McNamara and his colleagues have defined that as being less than 200 mL/kg/min left ventricular output. This cohort study of 30 infants post-ligation, by Afif El-Khuffash and colleagues at … Continue reading →

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Neonatal Updates : Therapeutic hypothermia

Posted on 21 March 2014 by Keith Barrington

Three recent articles dealing with the effects of therapeutic hypothermia: Drury PP, Gunn ER, Bennet L, Gunn AJ. Mechanisms of Hypothermic Neuroprotection. Clin Perinatol. 2014;41(1):161-75. the first is an excellent review article describing how hypothermia works, SPOILER ALERT, its mostly … Continue reading →

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Hypotension after PDA ligation

Posted on 19 March 2014 by Keith Barrington

A new prospective multi-center evaluation, of cardiac function and the causes of hypotension after PDA ligation, has just published data about adrenal function. Clyman RI, et al: Hypotension following patent ductus arteriosus ligation: The role of adrenal hormones. The Journal … Continue reading →

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HIP Protocol published

Posted on 13 March 2014 by Keith Barrington

The Hypotension in Preterms trial is about to get underway, with all the final hurdles just about cleared. Just at the right time our protocol has been published in ‘Neonatology’. Dempsey EM, Barrington KJ, Marlow N, O’Donnell CP, Miletin J, … Continue reading →

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Treatment of hypotension in the very preterm infant

Posted on 16 January 2014 by Keith Barrington

When hypotension should be treated and with what are important and difficult questions in the care of the very preterm infant. The international HIP collaboration (see the link in the side bar) has been funded to try and find some … Continue reading →

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