Tag Archives: oxygen toxicity

Oxygen is toxic in older kids too!

Posted on 22 February 2024 by Keith Barrington

A new large RCT from PICUs in the UK randomly compared 2 saturation target ranges, 88-92 and >94%. (Peters MJ, et al. Conservative versus liberal oxygenation targets in critically ill children (Oxy-PICU): a UK multicentre, open, parallel-group, randomised clinical trial. … Continue reading →

Posted in Neonatal Research | Tagged , , | 4 Comments

Automated oxygen control, what’s taking so long?

Posted on 29 April 2022 by Keith Barrington

A long long time ago, in a galaxy… actually quite near here, the idea of servo control of inspired oxygen was already in the air. At the time I first heard about it, the idea was to control FiO2 based … Continue reading →

Posted in Neonatal Research | Tagged , , , , | 1 Comment

Oxygen for resuscitation of the very preterm

Posted on 17 December 2019 by Keith Barrington

One of the paradoxes of neonatal respiratory control physiology is that hypoxia depresses respiration whilst hyperoxia stimulates breathing efforts. In fact it’s not such a paradox, prolonged hypoxia in adults decreases respiratory drive also. But could this be relevant in … Continue reading →

Posted in Neonatal Research | Tagged , , , | 2 Comments

Oxygen for preterm infants, what dose of this toxic drug is the right dose? #NeoEBM

Posted on 20 June 2018 by Keith Barrington

The NeoProm primary publication is the result of a prolonged gestation; I remember meetings over 15 years ago when Cynthia Cole from Boston was suggesting the idea, and although she was not, I think, finally an author on any of … Continue reading →

Posted in Neonatal Research | Tagged , , , , , | 1 Comment

Too much oxygen is bad for adults too!

Posted on 2 May 2018 by Keith Barrington

The systematic review of the neonatal oxygen saturation targeting trials Askie LM, et al. Effects of targeting lower versus higher arterial oxygen saturations on death or disability in preterm infants. Cochrane database of systematic reviews (Online). 2017;4:Cd011190. confirmed the increase … Continue reading →

Posted in Neonatal Research | Tagged , , , , | Leave a comment

Still more doubts about BOOSTing saturations?

Posted on 22 February 2016 by Keith Barrington

I won’t make a point-by-point response to Reese’s comments, mostly because I agree with most of them! Oxygen is toxic. Minimizing oxygen toxicity is a vitally important issue. Alarm fatigue is a major problem. In our NICU we performed an … Continue reading →

Posted in Neonatal Research | Tagged , , , , | 1 Comment

More Doubts about BOOSTing saturations?

Posted on 22 February 2016 by Keith Barrington

As I just mentioned I received another thoughtful comment from Reese Clark, which I reproduce in its entirety below: “After re-reading my post and at the risk of being a bit redundant with what Dr Barrington has already carefully presented … Continue reading →

Posted in Neonatal Research | Tagged , , , , | Leave a comment

Doubts about BOOSTING saturations?

Posted on 22 February 2016 by Keith Barrington

I received a very thoughtful comment from Reese Clark, who many of you will know as a leader in neonatology whose many years of experience and important scientific contributions to neonatology make him someone worth listening to. He has doubts … Continue reading →

Posted in Neonatal Research | Tagged , , , | 3 Comments

Retinopathy: up or down?

Posted on 17 November 2015 by Keith Barrington

The oxygen saturation targeting trials showed more retinopathy with higher oxygen saturation targets. Will this translate into more retinopathy in actual practice? Many units have increased their saturation targets as a result of those studies. This may indeed lead to … Continue reading →

Posted in Neonatal Research | Tagged , , | 3 Comments

Lower oxygen resuscitation for preterms?

Posted on 15 September 2015 by Keith Barrington

A new publication from a group of us in the CNN, suggests that the answer to that query is ‘not so fast’. Rabi Y, Lodha A, Soraisham A, Singhal N, Barrington K, Shah PS, et al. Outcomes of preterm infants following … Continue reading →

Posted in Neonatal Research | Tagged , , , | 4 Comments