Tag Archives: hypoxic ischemic encephalopathy

Imaging after therapeutic hypothermia: when to do the MRI (if at all)

Posted on 19 April 2023 by Keith Barrington

I had thought it was well settled that imaging soon after rewarming was as good for predicting outcomes in HIE as later imaging, but it seems that the timing, and the methodology are still uncertain. Tabacaru C, et al. Diffusion … Continue reading →

Posted in Neonatal Research | Tagged , , , , | Leave a comment

Cord milking and resuscitation, an alternative?

Posted on 2 September 2022 by Keith Barrington

My recent posts about resuscitation with an intact cord were rapidly followed by a publication of another multicentre randomized controlled trial, this time a cluster randomized crossover trial, of cord milking in babies who needed intervention. (Katheria AC, et al. … Continue reading →

Posted in Neonatal Research | Tagged , , , , | Leave a comment

Erythropoietin does not protect the brain, what next?

Posted on 27 July 2022 by Keith Barrington

The latest trial to fail to find a benefit of erythropoietin (Epo) for neonatal brain protection has just been published (Wu YW, et al. Trial of Erythropoietin for Hypoxic-Ischemic Encephalopathy in Newborns. N Engl J Med. 2022;387(2):148-59). The HEAL trial, … Continue reading →

Posted in Neonatal Research | Tagged , , , | 4 Comments

Should all asphyxiated babies have MR spectroscopy?

Posted on 21 December 2020 by Keith Barrington

MRI post-asphyxia, and post-rewarming, seems to be more predictive of long term outcomes than MRI at term for preterm infants. Imaging and analysis of the Apparent Diffusion Coefficient in the PLIC (posterior Limb of the Internal Capsule), for example, has … Continue reading →

Posted in Neonatal Research | Tagged , | Leave a comment

Diuretics as Anticonvulsants?

Posted on 16 December 2020 by Keith Barrington

In recent years there has been a lot of interest in neonatal seizures and how to treat them. Older studies confirmed that phenobarbitone (or phenobarbital, I never know these days) appears effective, but with limits; many babies have a partial … Continue reading →

Posted in Neonatal Research | Tagged , , , , | Leave a comment

Timing of MRI after HIE

Posted on 17 April 2015 by Keith Barrington

Three recent articles have investigated whether we should wait until a week or so after birth to perform brain imaging in infants with encephalopathy, or whether earlier imaging might be just as predictive. The three articles have consistent findings, which is … Continue reading →

Posted in Neonatal Research | Tagged , , , , | 3 Comments