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Meta
Tag Archives: Probiotics
More about Prebiotics
I don’t know if there is an “official” definition of prebiotics, but I think of them as molecules present in the diet that promote the growth of probiotic organisms. I believe that originally the term was applied only to molecules … Continue reading
Posted in Neonatal Research
Tagged Necrotising Enterocolitis, Prebiotics, Probiotics, Systematic Reviews
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Probiotics and NEC, the latest answer?
The updated Cochrane review of probiotics for prevention of NEC, sepsis and mortality has been published. Meta-analysis showed that probiotics may reduce the risk of NEC: RR 0.54, 95% CI 0.45 to 0.65 (54 trials, 10,604 infants; I2 = 17%); … Continue reading
Probiotics: are they cost effective?
Like almost any intervention in the NICU (even maternal breast milk requires pumps and equipment, and kangaroo care requires chairs) there is some cost associated with routine probiotic administration. A new publication attempts to calculate the cost-effectiveness relationship. (Craighead AF, … Continue reading
Posted in Neonatal Research
Tagged Cost effectiveness, Necrotising Enterocolitis, Probiotics
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Probiotics, can’t get enough…
All probiotics are not equal. I think it is clear, for example, that the probiotic fungi (Saccharomyces) studied in 2 small trials had no impact on NEC. In addition one of the largest and best trials (PiPS) from the UK … Continue reading
Posted in Neonatal Research
Tagged microbiome, Necrotising Enterocolitis, Probiotics
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Probiotics save the lives of preterm infants. Find a reliable source.
The American Gastroenterological Association has recently published its guidance about probiotics for various conditions. They found little evidence of benefit for most indications with the probable exception of preventing antibiotic-associated diarrhoea. The 8th indication that they reviewed was the prevention … Continue reading
Posted in Neonatal Research
Tagged Necrotising Enterocolitis, Probiotics, Systematic Reviews
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Do Probiotics work in the UK?
Seems like a dumb question I know, if they work in one country, surely they should work everywhere? It is sometimes difficult, however, to institute change based on studies that are done elsewhere, usually because there is an idea, or … Continue reading
Prebiotics and preterms and probiotics.
A selection of recent publications, regarding the issues in the title, that I find interesting and which seem to tell a consistent story. From Nick Embleton’s group the following interesting study (Stewart CJ, et al. Longitudinal development of the gut … Continue reading
Posted in Neonatal Research
Tagged breast milk, Necrotising Enterocolitis, Prebiotics, Probiotics, Sepsis
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Probiotics for extremely preterm infants
The use of probiotics for Necrotising enterocolitis prophylaxis in the very preterm is increasing across Canada. There are apparently, though, centers that will only give them to larger preterm infants, and not to the most immature. I think that is … Continue reading
Necrotizing Enterocolitis: manipulating the microbiome, part 3
Abdulkadir B, et al. Stool bacterial load in preterm infants with necrotising enterocolitis. Early Hum Dev. 2016;95:1-2. More work from the Newcastle group, this time the group decided not to look at the proportion of different bugs in the stools, … Continue reading
Prebiotics, Probiotics and the microbiome
A series of interesting recent articles: Yang J, et al. Application of Laser Capture Microdissection and 16S rRNA Gene Polymerase Chain Reaction in the Analysis of Bacteria Colonizing the Intestinal Tissue of Neonates With Necrotizing Enterocolitis. Pediatr Infect Dis J. … Continue reading
Posted in Neonatal Research
Tagged microbiome, Necrotising Enterocolitis, Probiotics
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