Tag Archives: Research Design

Research Outcomes in Neonatology : must do better.

Posted on 24 May 2019 by

When planning a research project with neonatal patients the first question should be, what am I investigating? The PICO outline : standing for Patients, Intervention, Controls (or comparison) and Outcome, is a standardized way of asking the simple question. If … Continue reading →

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To p or not to p, what is the alternative?

Posted on 3 April 2019 by

I started writing the previous post several weeks ago, and, of course, the ideas are not original with me, in fact, a whole recent issue of “The American Statistician” is dedicated to not just trying to eliminate talk of statistical … Continue reading →

Posted in Neonatal Research | Tagged , | 2 Comments

To p or not to p, that is the question.

Posted on 1 April 2019 by

I can’t claim preference for this title, although I wish I could. I copied it from an article published in an ENT journal (Buchinsky FJ, Chadha NK. To P or Not to P: Backing Bayesian Statistics. Otolaryngol Head Neck Surg. … Continue reading →

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Death or oxygen, which is worse?

Posted on 27 February 2019 by

We have a big problem in neonatal research. We have constructed composite outcomes that have become the “standard of design”, but are not of much use for anyone. Because we are, rightly, concerned that death and other diagnoses may be … Continue reading →

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Reading Research: Subgroups and Observational studies

Posted on 1 March 2017 by

In publications of randomized controlled trials, subgroup analyses are frequently performed. The idea behind such analyses being to determine whether one group or another has a different result to the overall results, for example, whether boys or girls have more … Continue reading →

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Two New Publications

Posted on 15 August 2016 by

After a few weeks break (for a number of reasons), I’m ready to start blogging again! I’m sure you have all missed the succinct and perceptive critiques of the recent neonatal literature, but today I will start with 2 publications … Continue reading →

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The best outcome variable for very preterm newborns?

Posted on 27 November 2015 by

Death or ‘neurodevelopmental impairment’ (NDI) as a combined outcome has become a sort of de facto standard as the primary outcome for neonatal clinical trials. Because many very preterm infants have developmental delay, intellectual and learning difficulties, and some have … Continue reading →

Posted in Clinical Practice Guidelines, Neonatal Research | Tagged , , , | 1 Comment