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Tag Archives: Research Design
Reading Research: Subgroups and Observational studies
In publications of randomized controlled trials, subgroup analyses are frequently performed. The idea behind such analyses being to determine whether one group or another has a different result to the overall results, for example, whether boys or girls have more … Continue reading
Two New Publications
After a few weeks break (for a number of reasons), I’m ready to start blogging again! I’m sure you have all missed the succinct and perceptive critiques of the recent neonatal literature, but today I will start with 2 publications … Continue reading
Posted in Neonatal Research
Tagged Ethics, Health Care Organization, mortality, Research Design
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The best outcome variable for very preterm newborns?
Death or ‘neurodevelopmental impairment’ (NDI) as a combined outcome has become a sort of de facto standard as the primary outcome for neonatal clinical trials. Because many very preterm infants have developmental delay, intellectual and learning difficulties, and some have … Continue reading
Conflicts of interest are not all financial, but they are conflicts none the less. Name change not required.
Another poorly argued article trying to minimize the reality of conflicts of interest in medical research. Cappola AR, FitzGerald GA. Confluence, not conflict of interest: Name change necessary. JAMA. 2015;314(17):1791-2. If someone stands to have a personal advantage as a result … Continue reading
Late Surfactant may not be effective, probably.
A large multi-center trial (n=511) led by Roberta Ballard has just been published. (Ballard RA, et al. Randomized Trial of Late Surfactant Treatment in Ventilated Preterm Infants Receiving Inhaled Nitric Oxide. J Pediatr 2015.) In this trial infants had similar … Continue reading
Posted in Neonatal Research
Tagged BPD, mortality, Randomized Controlled Trials, Research Design, surfactant treatment
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Murky Guidance
After the OHRP meetings and their evaluation of the SUPPORT controversy, the OHRP have now released what they call “Draft Guidance on Disclosing Reasonably Foreseeable Risks in Research Evaluating Standards of Care” The conclusion of the draft guidance starts with … Continue reading
What do parents of twins (and the twins) think about randomizing multiples
There has been some controversy recently about how we should randomize twins (and triplets or more) in neonatal trials. The question being whether randomizing the babies independently or randomizing them as a group is preferable. Those who wish to randomize … Continue reading
Posted in Neonatal Research
Tagged Randomized Controlled Trials, Research Design, twins
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