Category Archives: Neonatal Research

Two amazing trials, at the opposite ends of the spectrum. What a weird world.

In the most recent NEJM two trials impacting newborn/paediatric care. One including 3,211 preterm infants, which shows that a very simple intervention could save, I estimate, tens of thousands of lives each year at almost no cost; the other with … Continue reading

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What do you think are meaningful long term outcomes for preterm infants? Give your opinion!

Annie Janvier is part of a group of collaborators who are trying to get multiple opinions about meaningful outcomes in preterm babies. It is part of a project being run by the Canadian Follow-up Network CNFUN, which is called Parent-EPIQ. … Continue reading

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Which is worse; death or a low Bayley score? Comparing composite outcomes between groups, taking into account clinical priorities.

I keep harping on about this issue as I think we make a mistake in the design of our research studies when we include death and a much less important outcome in composite outcomes. For example in the STOP-BPD trial, … Continue reading

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Renal Function in the very immature preterm, what is a “normal” creatinine

The last time I blogged about this issue, there were a few comments from renal specialists which pointed out some limitations in my interpretation of the data. I defended myself admirably (it is my blog after all!) but I recognize … Continue reading

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Longer-term outcomes: what should we measure? part 2

I have made my concerns about developmental screening tests including the Bayley clear over the years, including in the previous post, which might make what I am going to say now seem odd: I do not think we should stop … Continue reading

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Longer term outcomes; what should we measure? part 1.

Many important trials include follow-up to about 2 years in order to ascertain longer-term effects. Such as this one: Adams-Chapman I, et al. Neurodevelopmental outcome of preterm infants enrolled in myo-inositol randomized controlled trial. J Perinatol. 2021. Ira Adams-Chapman was … Continue reading

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More thoughts about what to de-adopt

My post about de-adopting certain investigations or procedures in the NICU got a lot of suggestions and responses. Here are a few, either from the comments section or from Twitter. We should de-adopt the following: Dopamine. This is a suggestion … Continue reading

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Medication use in babies with bronchopulmonary dysplasia

A few recent studies have noted the marked variability between sites in the use of medications in preterm infants with BPD. Nelin TD, et al. The association between diuretic class exposures and enteral electrolyte use in infants developing grade 2 … Continue reading

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The ACOG patient information page; what should it say about 22, 23, 24 weekers?

I mentioned not so long ago that the web page of the US Obstetricians professional association has information for prospective parents of babies of less than 25 weeks gestation that is… questionable. They state, for example, the following : Medical … Continue reading

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What should we de-adopt in Neonatology?

When practices become ingrained in practice it can be very difficult to change them, even when new evidence becomes available, or a review of existing evidence points out that the practice is worthless. An editorial towards the end of last … Continue reading

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