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Meta
Category Archives: Neonatal Research
Protein pump inhibitors cause coeliac disease and asthma, and they are unnecessary.
OK, that title is perhaps slightly too definite, the publications that I wanted to discuss are observational studies, which can only prove associations, but it would be hard to perform the prospective controlled trials that would be necessary to prove … Continue reading
Reducing pain from retinopathy screening
Retinopathy screening is undoubtedly painful for preterm babies, formal evaluation with PIPP scores routinely exceed 10 during screening, and may exceed 14, meaning moderate to severe pain. As a planned procedure there is always opportunity for pre-emptive analgesia prior to … Continue reading
What dose of caffeine to use?
The dose of caffeine that we used for the CAP trial was the dose that was being widely used at the time. It seemed to be a safe dose, that did not require serum concentration surveillance, but was not based … Continue reading
Posted in Neonatal Research
Tagged Apnea, caffeine, long term outcomes, Randomized Controlled Trials
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Toxicity of antenatal steroids on the developing brain.
A new study from Finland this time, raises similar concerns to those from a Canadian study. (Raikkonen K, et al. Associations Between Maternal Antenatal Corticosteroid Treatment and Psychological Developmental and Neurosensory Disorders in Children. JAMA Netw Open. 2022;5(8):e2228518). It is … Continue reading
Cord milking and resuscitation, an alternative?
My recent posts about resuscitation with an intact cord were rapidly followed by a publication of another multicentre randomized controlled trial, this time a cluster randomized crossover trial, of cord milking in babies who needed intervention. (Katheria AC, et al. … Continue reading
Resuscitation before clamping the cord, some physiologic considerations
Delaying cord clamping until respiration is well established is a physiologically pleasing approach, and avoids the dramatic decrease in left ventricular preload, simultaneously with an increase in afterload that occurs with early clamping. But does delaying clamping during positive pressure … Continue reading
Is glucose gel safe? Is it necessary?
The Auckland group has been studying the treatment and implications of neonatal hypoglycaemia for many years now, with unique high quality studies. Two of their recent publications have addressed the safety of glucose gel for hypoglycaemia, the first (St Clair … Continue reading
Posted in Neonatal Research
Tagged Hypoglycemia, long term outcomes, microbiome, Randomized Controlled Trials
5 Comments
Anti VEGF treatment of retinopathy: and the long term?
There remains some doubt about the impacts on cerebral development, and thus on developmental progress of anti-VEGF treated babies. It is possible that there are cerebral effects of VEGF inhibition (or interception) and it isn’t clear what the exposure of … Continue reading
Anti-VEGF vs laser therapy for retinopathy, not worse, but not not worse?
A newer anti-VEGF drug has been invented, and evaluated in retinopathy therapy. This new drug aflibercept works differently to the “-mab” drugs we have been using. Those others are monoclonal antibodies (hence mab) directed against VEGF, whereas this new stuff … Continue reading
Posted in Neonatal Research
Tagged Randomized Controlled Trials, Retinopathy of Prematurity
1 Comment
Resuscitation before clamping the cord?
Delayed cord clamping is now standard of care for all deliveries, at term or preterm. In term deliveries it leads to improved iron stores in the baby which difference persists during the first year of life. In very preterm infants … Continue reading
Posted in Neonatal Research
Tagged Delayed Cord Clamping, Randomized Controlled Trials, Resuscitation
4 Comments
Neonatal Research 