Tag Archives: microbiome

Necrotizing Enterocolitis: manipulating the microbiome, part 3

Abdulkadir B, et al. Stool bacterial load in preterm infants with necrotising enterocolitis. Early Hum Dev. 2016;95:1-2.  More work from the Newcastle group, this time the group decided not to look at the proportion of different bugs in the stools, … Continue reading

Posted in Neonatal Research | Tagged , , , , | 2 Comments

Necrotizing Enterocolitis: manipulating the microbiome, part 2

The Newcastle, UK, group has published an article about the intestinal microbiome of babies receiving routine probiotic prophylaxis. Abdulkadir B, et al. Routine Use of Probiotics in Preterm Infants: Longitudinal Impact on the Microbiome and Metabolome. Neonatology. 2016;109(4):239-47. The authors studied 7 … Continue reading

Posted in Neonatal Research | Tagged , | 2 Comments

Necrotizing Enterocolitis: manipulating the microbiome, part 1

Some very interesting recent publications about NEC, so I will post a multi-part bumper posting. The first has just been published (in tomorrow’s Lancet) Warner BB, et al. Gut bacteria dysbiosis and necrotising enterocolitis in very low birthweight infants: a prospective … Continue reading

Posted in Neonatal Research | Tagged , | Leave a comment

Prebiotics, Probiotics and the microbiome

A series of interesting recent articles: Yang J, et al. Application of Laser Capture Microdissection and 16S rRNA Gene Polymerase Chain Reaction in the Analysis of Bacteria Colonizing the Intestinal Tissue of Neonates With Necrotizing Enterocolitis. Pediatr Infect Dis J. … Continue reading

Posted in Neonatal Research | Tagged , , | Leave a comment

Frozen poop sounds much more palatable

Fecal transplants are effective in treatment of persistent clostridium difficile infections. The publication showing that, in the small RCT published in the PNEJM, was remarkable in the pre-screened donors who were ready and available to produce a “donation” on demand. … Continue reading

Posted in Neonatal Research | Tagged | Leave a comment

Stop the Antibiotics!

We know that prolonged antibiotic use in preterm babies increase their chance of later developing NEC. The assumption being that the disturbance of the intestinal flora leads to the increase in susceptibility. Here is some more direct evidence to support … Continue reading

Posted in Neonatal Research | Tagged , , | 4 Comments

Your mother is the source of your microbiome

An interesting review article from last year (free access) which discusses information from many different species, several non-mammalian, that show that, not too surprisingly, our mothers are the source of our microbiome. They speculate that the bacterial contamination of breast … Continue reading

Posted in Neonatal Research | Tagged , | Leave a comment