Tag Archives: microbiome

Where does sepsis come from?

Posted on 25 November 2019 by

One of the findings of the recent SIFT trial was that although the babies in the fast feeding group had shorter duration of parenteral nutrition, TPN, (and presumably of central lines), they did not have less late-onset sepsis, LOS. Why … Continue reading →

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Quoted in “nature”

Posted on 5 April 2018 by

An interesting and well-written article in nature (or, at least, a supplement called “nature outlook”) by a scientific journalist Sarah DeWeerdt has appeared, discussing the acquisition of the intestinal microbiome by newborn infants. She discusses premature infants and the role … Continue reading →

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Necrotizing Enterocolitis: manipulating the microbiome, part 3

Posted on 9 May 2016 by

Abdulkadir B, et al. Stool bacterial load in preterm infants with necrotising enterocolitis. Early Hum Dev. 2016;95:1-2.  More work from the Newcastle group, this time the group decided not to look at the proportion of different bugs in the stools, … Continue reading →

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Necrotizing Enterocolitis: manipulating the microbiome, part 2

Posted on 6 May 2016 by

The Newcastle, UK, group has published an article about the intestinal microbiome of babies receiving routine probiotic prophylaxis. Abdulkadir B, et al. Routine Use of Probiotics in Preterm Infants: Longitudinal Impact on the Microbiome and Metabolome. Neonatology. 2016;109(4):239-47. The authors studied 7 … Continue reading →

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Necrotizing Enterocolitis: manipulating the microbiome, part 1

Posted on 6 May 2016 by

Some very interesting recent publications about NEC, so I will post a multi-part bumper posting. The first has just been published (in tomorrow’s Lancet) Warner BB, et al. Gut bacteria dysbiosis and necrotising enterocolitis in very low birthweight infants: a prospective … Continue reading →

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Prebiotics, Probiotics and the microbiome

Posted on 2 October 2015 by

A series of interesting recent articles: Yang J, et al. Application of Laser Capture Microdissection and 16S rRNA Gene Polymerase Chain Reaction in the Analysis of Bacteria Colonizing the Intestinal Tissue of Neonates With Necrotizing Enterocolitis. Pediatr Infect Dis J. … Continue reading →

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Frozen poop sounds much more palatable

Posted on 7 November 2014 by

Fecal transplants are effective in treatment of persistent clostridium difficile infections. The publication showing that, in the small RCT published in the PNEJM, was remarkable in the pre-screened donors who were ready and available to produce a “donation” on demand. … Continue reading →

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Stop the Antibiotics!

Posted on 21 February 2014 by

We know that prolonged antibiotic use in preterm babies increase their chance of later developing NEC. The assumption being that the disturbance of the intestinal flora leads to the increase in susceptibility. Here is some more direct evidence to support … Continue reading →

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Your mother is the source of your microbiome

Posted on 12 February 2014 by

An interesting review article from last year (free access) which discusses information from many different species, several non-mammalian, that show that, not too surprisingly, our mothers are the source of our microbiome. They speculate that the bacterial contamination of breast … Continue reading →

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Probiotics : Time for Action

Posted on 10 February 2014 by

As I have noted before on this blog, our article showing the effects of the introduction of routine probiotics in our NICU has been published on-line. The Journal of Pediatrics decided to accompany it with an editorial by William Tarnow-Mordi … Continue reading →

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