Tag Archives: microbiome

It’s Raining Antibiotics

Posted on 8 November 2022 by Keith Barrington

Early onset sepsis is a serious condition with a substantial morbidity, and, thankfully, a relatively low mortality in recent years. Prompt recognition and early treatment are essential, but early clinical signs and risk factors tend to be non-specific. As a … Continue reading →

Posted in Neonatal Research | Tagged , , , | 3 Comments

Is glucose gel safe? Is it necessary?

Posted on 25 August 2022 by Keith Barrington

The Auckland group has been studying the treatment and implications of neonatal hypoglycaemia for many years now, with unique high quality studies. Two of their recent publications have addressed the safety of glucose gel for hypoglycaemia, the first (St Clair … Continue reading →

Posted in Neonatal Research | Tagged , , , | 5 Comments

World NEC awareness day.

Posted on 17 May 2022 by Keith Barrington

As we approach world NEC awareness day (May 17th) I thought I’d do a quick PubMed search to see if I’ve missed anything recently, so I started typing “necrotizing” in the search bar, which immediately suggested “necrotizing enterocolitis” as one … Continue reading →

Posted in Neonatal Research | Tagged , , , | Leave a comment

More musings on the microbiome

Posted on 21 January 2022 by Keith Barrington

We are fortunate in neonatology to not have to worry about C difficile, partly because the name has been changed for this germ as well (now Clostridioides, rather than Clostridium), and it is one less name change to keep up … Continue reading →

Posted in Neonatal Research | Tagged , , | Leave a comment

Probiotics in preterms; what’s new? Part 1

Posted on 18 January 2022 by Keith Barrington

I haven’t, surprisingly, posted about probiotics recently, but there are some new findings in the literature that warrant discussion. Granger C, et al. Necrotising enterocolitis, late-onset sepsis and mortality after routine probiotic introduction in the UK. Arch Dis Child Fetal … Continue reading →

Posted in Neonatal Research | Tagged , , | 6 Comments

Probiotics, can’t get enough…

Posted on 27 August 2020 by Keith Barrington

All probiotics are not equal. I think it is clear, for example, that the probiotic fungi (Saccharomyces) studied in 2 small trials had no impact on NEC. In addition one of the largest and best trials (PiPS) from the UK … Continue reading →

Posted in Neonatal Research | Tagged , , | Leave a comment

Where does sepsis come from?

Posted on 25 November 2019 by Keith Barrington

One of the findings of the recent SIFT trial was that although the babies in the fast feeding group had shorter duration of parenteral nutrition, TPN, (and presumably of central lines), they did not have less late-onset sepsis, LOS. Why … Continue reading →

Posted in Neonatal Research | Tagged , , , | Leave a comment

Quoted in “nature”

Posted on 5 April 2018 by Keith Barrington

An interesting and well-written article in nature (or, at least, a supplement called “nature outlook”) by a scientific journalist Sarah DeWeerdt has appeared, discussing the acquisition of the intestinal microbiome by newborn infants. She discusses premature infants and the role … Continue reading →

Posted in Neonatal Research | Tagged , , | Leave a comment

Necrotizing Enterocolitis: manipulating the microbiome, part 3

Posted on 9 May 2016 by Keith Barrington

Abdulkadir B, et al. Stool bacterial load in preterm infants with necrotising enterocolitis. Early Hum Dev. 2016;95:1-2.  More work from the Newcastle group, this time the group decided not to look at the proportion of different bugs in the stools, … Continue reading →

Posted in Neonatal Research | Tagged , , , , | 2 Comments

Necrotizing Enterocolitis: manipulating the microbiome, part 2

Posted on 6 May 2016 by Keith Barrington

The Newcastle, UK, group has published an article about the intestinal microbiome of babies receiving routine probiotic prophylaxis. Abdulkadir B, et al. Routine Use of Probiotics in Preterm Infants: Longitudinal Impact on the Microbiome and Metabolome. Neonatology. 2016;109(4):239-47. The authors studied 7 … Continue reading →

Posted in Neonatal Research | Tagged , | 2 Comments