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Recent Posts
- Two amazing trials, at the opposite ends of the spectrum. What a weird world.
- What do you think are meaningful long term outcomes for preterm infants? Give your opinion!
- Which is worse; death or a low Bayley score? Comparing composite outcomes between groups, taking into account clinical priorities.
- Renal Function in the very immature preterm, what is a “normal” creatinine
- Longer-term outcomes: what should we measure? part 2
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Meta
Tag Archives: microbiome
Probiotics, can’t get enough…
All probiotics are not equal. I think it is clear, for example, that the probiotic fungi (Saccharomyces) studied in 2 small trials had no impact on NEC. In addition one of the largest and best trials (PiPS) from the UK … Continue reading
Posted in Neonatal Research
Tagged microbiome, Necrotising Enterocolitis, Probiotics
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Where does sepsis come from?
One of the findings of the recent SIFT trial was that although the babies in the fast feeding group had shorter duration of parenteral nutrition, TPN, (and presumably of central lines), they did not have less late-onset sepsis, LOS. Why … Continue reading
Posted in Neonatal Research
Tagged enteral feeding, infection control, microbiome, Sepsis
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Quoted in “nature”
An interesting and well-written article in nature (or, at least, a supplement called “nature outlook”) by a scientific journalist Sarah DeWeerdt has appeared, discussing the acquisition of the intestinal microbiome by newborn infants. She discusses premature infants and the role … Continue reading
Posted in Neonatal Research
Tagged breast milk, microbiome, Necrotising Enterocolitis
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Necrotizing Enterocolitis: manipulating the microbiome, part 3
Abdulkadir B, et al. Stool bacterial load in preterm infants with necrotising enterocolitis. Early Hum Dev. 2016;95:1-2. More work from the Newcastle group, this time the group decided not to look at the proportion of different bugs in the stools, … Continue reading
Necrotizing Enterocolitis: manipulating the microbiome, part 2
The Newcastle, UK, group has published an article about the intestinal microbiome of babies receiving routine probiotic prophylaxis. Abdulkadir B, et al. Routine Use of Probiotics in Preterm Infants: Longitudinal Impact on the Microbiome and Metabolome. Neonatology. 2016;109(4):239-47. The authors studied 7 … Continue reading
Necrotizing Enterocolitis: manipulating the microbiome, part 1
Some very interesting recent publications about NEC, so I will post a multi-part bumper posting. The first has just been published (in tomorrow’s Lancet) Warner BB, et al. Gut bacteria dysbiosis and necrotising enterocolitis in very low birthweight infants: a prospective … Continue reading
Prebiotics, Probiotics and the microbiome
A series of interesting recent articles: Yang J, et al. Application of Laser Capture Microdissection and 16S rRNA Gene Polymerase Chain Reaction in the Analysis of Bacteria Colonizing the Intestinal Tissue of Neonates With Necrotizing Enterocolitis. Pediatr Infect Dis J. … Continue reading
Posted in Neonatal Research
Tagged microbiome, Necrotising Enterocolitis, Probiotics
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Frozen poop sounds much more palatable
Fecal transplants are effective in treatment of persistent clostridium difficile infections. The publication showing that, in the small RCT published in the PNEJM, was remarkable in the pre-screened donors who were ready and available to produce a “donation” on demand. … Continue reading
Stop the Antibiotics!
We know that prolonged antibiotic use in preterm babies increase their chance of later developing NEC. The assumption being that the disturbance of the intestinal flora leads to the increase in susceptibility. Here is some more direct evidence to support … Continue reading
Your mother is the source of your microbiome
An interesting review article from last year (free access) which discusses information from many different species, several non-mammalian, that show that, not too surprisingly, our mothers are the source of our microbiome. They speculate that the bacterial contamination of breast … Continue reading
