As far as I can see, this trial has no acronym, which isn’t a big deal, but it also doesn’t show up on trial registry searches, which is a big deal. Trials must be registered before starting them, it ensures that protocols, sample sizes, outcomes, analyses, and so on, do not change without explanation. And it ensures that trials don’t end up being hidden and unpublished. The trial may have been registered, I just can’t find it.
I would call this trial PROPER, Pre-threshold RoP, Evaluation of pRopranolol! The authors can have that acronym for free if they want! How generous I am; unfortunately my Spanish is not good enough to generate a Spanish acronym.
In a single center trial, Aldo Bancalari and colleagues from Concepcion in Chile randomized 62 VLBW infants with stage 2 or 3 RoP in zone 2 or 3 (without plus disease) to oral propranolol or control (I am not sure if there was a placebo or not).
Progression to treatment thresholds (laser or intravitreal anti-VEGF treatment) was much less frequent with propanolol, with 28/31 (90%) having a favourable evolution, compared to 17/31 (55%) of controls. Which is a big difference unlikely to be due to chance alone. One of the propranolol babies was hypoglycemic on day 1, and there were no other side effects noted.
As I was creating this post, I realized that it actually looks like the authors have already published the results of this trial at an earlier stage, when they had enrolled 47 babies. That is really not appropriate; repeated analysis and presentation of results as they accumulate inflates risks of bias, dramatically. I was quite excited by this trial when I first saw it, but it looks now that it might not be a good use of my acronym, and perhaps it isn’t that proper!
**UPDATE, I have now received the full text of the previous publication, and that publication seems to refer to a cohort of treated babies that they compared to a historical control group (as mentioned by Ben Stenson in his comment below) and therefore this is probably a PROPER publication after all, I apologize to the authors if I mischaracterized this trial***
I think it is clear that we need… A Large Multicentre Trial of Propranolol in the Early Stages of RoP to Prevent Progression. Which we could call “PREPARE” the PREvention of the Progression of REtinopathy trial. I claim priority for this acronym. PORKY would work too, if we could work out how to get the k in there.