Tag Archives: Randomized Controlled Trials

Does LISA protect your brain?

A few years ago now a multicenter RCT among infants of 23 to 26 weeks gestation showed that LISA was possible in even these most immature infants., NINSAPP. Kribs A, et al. Nonintubated Surfactant Application vs Conventional Therapy in Extremely … Continue reading

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Delayed cord clamping in the very preterm

I haven’t written about this issue in a while, the APTS trial, and the systematic review which was published at about the same time appeared to show definitively that there was a reduction in mortality with delayed clamping compared to … Continue reading

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Diagnosing seizures in the newborn: a small step forward

The use of continuous EEG has become much more frequent in the NICU in recent years. It has become clear that clinical recognition of seizures, both those with and without clinical convulsions (which I will call electrographic seizures for all … Continue reading

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Dexamethasone ENT doses

Although we have a great group of ENT surgeons at my hospital, we do have one bone of contention; at least, there is just one bone left since they have agreed that you cannot diagnose reflux by performing a laryngoscopy! … Continue reading

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Lactoferrin: Does it decrease late-onset sepsis?

The first multicentre trial of bovine lactoferrin supplementation in preterm infants showed a dramatic reduction in late-onset sepsis of about 70%. I was very excited when I first saw Paolo Manzoni’s trial and rushed to set up a pilot in … Continue reading

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When should we start Parenteral Nutrition?

Following on from the previous post: This all brings me to a larger and very thorny issue, which is whether we should even be routinely starting parenteral nutrition (PN) immediately after birth at all! I hate to discuss this, as … Continue reading

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How much Intravenous lipid should we start with?

Since I started neonatology (just a little over 5 years ago…) we have given intravenous lipid emulsions starting at low doses and progressively increasing. As a reminder to everyone, when intralipid (as I will call it to refer to all … Continue reading

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How much should we feed babies?

Surely after 60 years of neonatal intensive care, we have figured out what volume of milk to give to small preterm babies? Our local feeding protocol uses a standard of 160 mL/kg/d, which we will increase to 170 mL/kg/d if … Continue reading

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ELVIS is alive!

I was searching through the lyrics of ELVIS songs for a quote that might be more apt for this new blog post than “It’s now or ever”, which I have used previously, when I realized that I am a loser, … Continue reading

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Does erythropoietin prophylaxis prevent NEC? Unreliable data.

Routine erythropoietin administration from early life in very preterm babies has been postulated to be neuro-protective. Unfortunately, despite some early promising results, 2 large well-performed RCTs showed no benefit, including the largest with 750 babies under 28 weeks, which showed … Continue reading

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