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Meta
Tag Archives: mortality
International variations in outcomes of extreme preterm infants
A publication from an international collaboration of neonatal databases has just appeared, (Lui K, et al. Trends in Outcomes for Neonates Born Very Preterm and Very Low Birth Weight in 11 High-Income Countries. J Pediatr. 2019). It makes very interesting … Continue reading
Posted in Neonatal Research
Tagged intracranial hemorrhage, mortality, Retinopathy of Prematurity
1 Comment
Platelet transfusion threshholds: 25,000 even for the highest risk infants?
The Planet-2 trial that I posted about when it first came out showed no benefit among preterm infants, <34 weeks gestation when they received platelet transfusions at a threshold of 50,00 compared to waiting until they dropped to 25,000. I … Continue reading
Posted in Neonatal Research
Tagged mortality, Platelets, Randomized Controlled Trials
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Not futile any more; survival and long term outcomes at 22 weeks.
Imagine, if you will, that you work at a breast cancer center with moderately good results, but you have decided, as a group, to not offer therapy to women with stage 4- triple negative lesions. Survival is so low, you … Continue reading
Death or oxygen, which is worse?
We have a big problem in neonatal research. We have constructed composite outcomes that have become the “standard of design”, but are not of much use for anyone. Because we are, rightly, concerned that death and other diagnoses may be … Continue reading
Posted in Neonatal Research
Tagged mortality, Randomized Controlled Trials, Research Design, steroids
6 Comments
Active intervention at 22 weeks gestation, is it futile?
In order to respond to the question posed in the title we need first to agree on what “futile” means. It could mean “it never works” or, “it can work but the ultimate result is so bad that it isn’t … Continue reading
All that pneumatoses is not NEC
OK, I know pneumatose is not a verb, but I thought it was a cute title. What is NEC, anyway? Necrotizing Enterocolitis, of course, you might reply. But it’s not as simple as that. The very preterm baby who deteriorates … Continue reading
Posted in Neonatal Research
Tagged long term outcomes, mortality, Necrotising Enterocolitis
1 Comment
Oxygen for preterm infants, what dose of this toxic drug is the right dose? #NeoEBM
The NeoProm primary publication is the result of a prolonged gestation; I remember meetings over 15 years ago when Cynthia Cole from Boston was suggesting the idea, and although she was not, I think, finally an author on any of … Continue reading
PAS 2108 No4: you little SCAMP!
In the part of England where I was born and spent the early years of my life, and where my parents are from, the Manchester region, ‘scamp’ was a sort of affectionate term for a young child who had done … Continue reading
PAS 2018 No3: Should we TOLERATE the PDA?
This was another large multicenter trial, designed to determine if routine attempts to close a moderate to large PDA at the end of the first postnatal week decreases the duration of patency, and the incidence of the combined outcome “need … Continue reading
PAS 2018 No1: SAIL away (and another mention by a science journalist).
For some reason there is a small epidemic (n=2, that’s a pico-epidemic) of articles about probiotics and necrotising enterocolitis this year in the mainstream press. I was interviewed, and I am mentioned again, in this article on the NOVA “next” … Continue reading
Posted in Neonatal Research
Tagged mortality, Randomized Controlled Trials, Resuscitation
2 Comments
Neonatal Research 