Tag Archives: Randomized Controlled Trials

PAS 2018 No6: Brett, the HUNTER

Posted on 12 May 2018 by Keith Barrington

Brett Manley from Melbourne is now the person in the world with the greatest trial experience in the use of high flow nasal cannulae in the newborn. He has been the HIPSTER, and is now the HUNTER, I can’t find … Continue reading →

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PAS 2018 No5: the trial with no name… propranolol for early RoP, a proper trial.

Posted on 11 May 2018 by Keith Barrington

As far as I can see, this trial has no acronym, which isn’t a big deal, but it also doesn’t show up on trial registry searches, which is a big deal. Trials must be registered before starting them, it ensures … Continue reading →

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PAS 2108 No4: you little SCAMP!

Posted on 10 May 2018 by Keith Barrington

In the part of England where I was born and spent the early years of my life, and where my parents are from, the Manchester region, ‘scamp’ was a sort of affectionate term for a young child who had done … Continue reading →

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PAS 2018 No3: Should we TOLERATE the PDA?

Posted on 10 May 2018 by Keith Barrington

This was another large multicenter trial, designed to determine if routine attempts to close a moderate to large PDA at the end of the first postnatal week decreases the duration of patency, and the incidence of the combined outcome “need … Continue reading →

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PAS 2018 No2: let’s STOP-BPD

Posted on 10 May 2018 by Keith Barrington

The STOP-BPD trial was a multicenter trial from Holland, (registered as NTR2768) over 180 babies were randomized to each arm of this trial, they were <30 weeks or less than 1250 g at birth, and were still ventilated at 2 … Continue reading →

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PAS 2018 No1: SAIL away (and another mention by a science journalist).

Posted on 9 May 2018 by Keith Barrington

For some reason there is a small epidemic (n=2, that’s a pico-epidemic) of articles about probiotics and necrotising enterocolitis this year in the mainstream press. I was interviewed, and I am mentioned again, in this article on the NOVA “next” … Continue reading →

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Regular universal antibiotics to reduce infant mortality?

Posted on 3 May 2018 by Keith Barrington

This (Keenan JD, et al. Azithromycin to Reduce Childhood Mortality in Sub-Saharan Africa. The New England journal of medicine. 2018;378(17):1583-92 Open Access) is a new multicenter cluster randomized trial of giving all infants in a community regular azithromycin. If that … Continue reading →

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Too much oxygen is bad for adults too!

Posted on 2 May 2018 by Keith Barrington

The systematic review of the neonatal oxygen saturation targeting trials Askie LM, et al. Effects of targeting lower versus higher arterial oxygen saturations on death or disability in preterm infants. Cochrane database of systematic reviews (Online). 2017;4:Cd011190. confirmed the increase … Continue reading →

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Its now or… later? A good question to ask ELVIS.

Posted on 19 April 2018 by Keith Barrington

This study probably wins the prize for the best trial name in neonatal history, the Early or Late Ventricular Intervention Study, ELVIS. de Vries LS, et al. Treatment thresholds for intervention in posthaemorrhagic ventricular dilation: a randomised controlled trial. Archives … Continue reading →

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Disseminated Intravascular Coagulation, does it make you feel like a DIC?

Posted on 4 April 2018 by Keith Barrington

Influenza is crap. Especially when you get it even though you have had the vaccine! The break in blog posts has been due to an assortment of viral illnesses, culminating in the “flu” and then followed by spring break, followed … Continue reading →

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