Tag Archives: Randomized Controlled Trials

Measure gastric residuals? Safe to stop?

Posted on 30 April 2019 by Keith Barrington

A new RCT published in JAMA pediatrics compared growth and other clinical outcomes between infants <33 weeks gestation and <1250g who were managed with routine gastric residual measurements or without. (Parker LA, et al. Effect of Gastric Residual Evaluation on … Continue reading →

Posted in Neonatal Research | Tagged , , , | 1 Comment

Platelet transfusions don’t close the PDA, but they may increase IVH

Posted on 13 April 2019 by Keith Barrington

I would never have actually thought to ask the question whether platelet transfusion might close the PDA, although early thrombocytopenia is associated with persistent PDA, and platelet plugs seem to be part of the mechanism of closure. A group in … Continue reading →

Posted in Neonatal Research | Tagged , , , | 2 Comments

Death or oxygen, which is worse?

Posted on 27 February 2019 by Keith Barrington

We have a big problem in neonatal research. We have constructed composite outcomes that have become the “standard of design”, but are not of much use for anyone. Because we are, rightly, concerned that death and other diagnoses may be … Continue reading →

Posted in Neonatal Research | Tagged , , , | 6 Comments

Under Pressure…

Posted on 7 November 2018 by Keith Barrington

This post “under pressure” isn’t about the classic collaboration between David Bowie and Queen at Live Aid, rather it is about how to wean CPAP. Should we trial preterm babies off for a period every day, or either progressively reduce … Continue reading →

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Heads up?

Posted on 1 November 2018 by Keith Barrington

A new RCT published in the Journal of Perinatology suggests that a midline head position with head elevated at 30 degrees might reduce severe intracranial hemorrhage. (Kochan M, et al. Elevated midline head positioning of extremely low birth weight infants: … Continue reading →

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Surfactant by nebulisation

Posted on 4 October 2018 by Keith Barrington

After the PAS meeting I blogged about a presented abstract of nebulized lucinactant, which showed a possible reduction in needing intubation among babies on CPAP who received the surfactant, compared to controls. A new publication from Perth (Minocchieri S, et … Continue reading →

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Oxygen for preterm infants, what dose of this toxic drug is the right dose? #NeoEBM

Posted on 20 June 2018 by Keith Barrington

The NeoProm primary publication is the result of a prolonged gestation; I remember meetings over 15 years ago when Cynthia Cole from Boston was suggesting the idea, and although she was not, I think, finally an author on any of … Continue reading →

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Even more thoughts on breast milk fortification

Posted on 18 June 2018 by Keith Barrington

I thought I would discuss the new study by O’Connor and colleagues in a little more detail (O’Connor DL, et al. Nutrient enrichment of human milk with human and bovine milk-based fortifiers for infants born weighing <1250 g: a randomized … Continue reading →

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Just needle it! #NeoEBM

Posted on 16 May 2018 by Keith Barrington

I didn’t post much about last year’s PAS (and I am not sure I will have the energy in future years either) there are often disappointments and surprises, abstrracts presented as platforms in important sessions that should not have been, … Continue reading →

Posted in Neonatal Research | Tagged , | 3 Comments

PAS 2018: the wrap-up.

Posted on 14 May 2018 by Keith Barrington

A general comment about these PAS 2018 blog posts. I think we should be very careful about changing practice based on an abstract. We should respect peer review, with all its limitations, and we should always consider new research in … Continue reading →

Posted in Neonatal Research | Tagged , , , , | 2 Comments