Tag Archives: Randomized Controlled Trials

Early low dose hydrocortisone seems to not affect medium term development; PREMILOC outcomes at 22 months.

Posted on 18 April 2017 by Keith Barrington

The PREMILOC trial was a multi-center RCT of hydrocortisone, 0.5mg/kg twice per day for 7 days followed by 0.5 mg/kg per day for 3 days, given starting within 24 hours of age to infants of 24 to less than 28 … Continue reading →

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Fluid restriction to prevent BPD?

Posted on 14 February 2017 by Keith Barrington

In response to my previous post, one of the comments was a question about fluid volumes in the first few days of life, and whether fluid and/or sodium intake was important for the development of BPD during the early neonatal … Continue reading →

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Fluid restriction as treatment for BPD? This time with the summary of findings table.

Posted on 13 February 2017 by Keith Barrington

I realize that many of my gentle readers may not have access to the Cochrane reviews in full text as soon as they are published. The NICHD do provide free access to the neonatal reviews, (together with a useful introduction … Continue reading →

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New Publication: Does fluid restriction improve the clinical status of babies with BPD?

Posted on 10 February 2017 by Keith Barrington

I have never been convinced that fluid restriction is a good thing for kids with BPD. I think the common practice came about because of the short-term improvements in lung function that sometimes follow if you start diuretics. The idea … Continue reading →

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Should we freeze maternal breast milk in the NICU? Pasteurize it?

Posted on 1 February 2017 by Keith Barrington

Maternal breast milk is what we should be giving to every preterm infant as much as possible. But we know that there are cases of transmission of cytomegalovirus (CMV) and reports of transmission of other pathogens to babies from breast … Continue reading →

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Happy New Review no. 2; Inhaled NO in the full term infant

Posted on 17 January 2017 by Keith Barrington

We have also updated the Cochrane review of inhaled NO in the term infant. (Barrington KJ, Finer N, Pennaforte T, Altit G. Nitric oxide for respiratory failure in infants born at or near term. Cochrane database of systematic reviews (Online). … Continue reading →

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Happy New Year! And Happy Reading; an update of the Cochrane review: nitric oxide in the preterm

Posted on 13 January 2017 by Keith Barrington

A major revision of the Cochrane review of inhaled nitric oxide gas in the preterm infant is now available. (Barrington KJ, Finer N, Pennaforte T. Inhaled nitric oxide for respiratory failure in preterm infants. Cochrane database of systematic reviews (Online). … Continue reading →

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Antenatal Steroids closer to term?

Posted on 4 November 2016 by Keith Barrington

A new systematic review in the BMJ (Saccone G, Berghella V. Antenatal corticosteroids for maturity of term or near term fetuses: systematic review and meta-analysis of randomized controlled trials. BMJ. 2016;355:i5044) includes 3 studies which examined the use of antenatal … Continue reading →

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It doesn’t make much difference how often we feed babies

Posted on 29 September 2016 by Keith Barrington

Over the years there have a number of studies comparing two different feeding regimes. Most recently there has been a comparison of 2 hourly vs 3 hourly feeds and a comparison of feeds every 3 hours compared to 4 feeds … Continue reading →

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Hey, doctor, leave those guts alone!

Posted on 24 August 2016 by Keith Barrington

Intestinal function is often sluggish after preterm delivery. Establishing early enteral nutrition, the goal of all of us, is interrupted often by repeated regurgitation, or large residuals (if you measure them) or abdominal distension. There are also reported correlations between … Continue reading →

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