Author Archives: Keith Barrington

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About Keith Barrington

I am a neonatologist and clinical researcher at Sainte Justine University Health Center in Montréal

Surfactant without intubation, where are we?

Posted on 4 February 2016 by Keith Barrington

A recent trial from Germany tried to answer the question of whether giving surfactant through a thin catheter while the baby was on CPAP would reduce “death or BPD” compared to intubation for surfactant. Kribs A, et al. Nonintubated Surfactant Application … Continue reading →

Posted in Neonatal Research | Tagged , , , | 1 Comment

When to deliver after Preterm Ruptured Membranes

Posted on 2 February 2016 by Keith Barrington

I have often wondered why my obstetrical colleagues would often induce labour once a woman with ruptured membranes reached 34 weeks. I wasn’t aware of any data to support doing this, or, on the other hand, any good data to … Continue reading →

Posted in Neonatal Research | Tagged , , | 2 Comments

How frequent is Acute Kidney Injury in the NICU? Not as frequent as some publications would have you believe.

Posted on 25 January 2016 by Keith Barrington

One recent publication states that 30% of all their babies under 30 weeks gestation had Acute Kidney Injury (AKI from now on). Another from a couple of years ago reports 40% of all their babies under 1500g had AKI. Both … Continue reading →

Posted in Neonatal Research | 8 Comments

All results must be published, and all data available.

Posted on 25 January 2016 by Keith Barrington

Support for the All trials campaign has been growing, but progress seems to be slow. There are still many trials that are not published, and the impacts on science based medicine are substantial. Recently, two articles by former participants in … Continue reading →

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Medium Term outcomes after neonatal hypoglycemia

Posted on 22 January 2016 by Keith Barrington

A new publication from the CHYLD program that I blogged about previously: Harris DL, et al. Outcome at 2 Years after Dextrose Gel Treatment for Neonatal Hypoglycemia: Follow-Up of a Randomized Trial. The Journal of pediatrics. 2015. In this paper … Continue reading →

Posted in Neonatal Research | 1 Comment

Back to Blogging, and publishing!

Posted on 22 January 2016 by Keith Barrington

A prolonged break, which occurred for various reasons, is at an end. I have a few posts lined up for the next few days, but will start with news about a new publication, an editorial I wrote with one of … Continue reading →

Posted in Neonatal Research | 1 Comment

Proud to be a Canadian, again.

Posted on 16 December 2015 by Keith Barrington

As a lifelong socialist, I couldn’t bring myself to vote Liberal in our last election. I would have been severely tempted, but I was fortunate to live in the constituency of Tom Mulcair, my primary motivation was “anybody but Harper”. Justin … Continue reading →

Posted in Neonatal Research | 1 Comment

The best outcome variable for very preterm newborns?

Posted on 27 November 2015 by Keith Barrington

Death or ‘neurodevelopmental impairment’ (NDI) as a combined outcome has become a sort of de facto standard as the primary outcome for neonatal clinical trials. Because many very preterm infants have developmental delay, intellectual and learning difficulties, and some have … Continue reading →

Posted in Clinical Practice Guidelines, Neonatal Research | Tagged , , , | 1 Comment

An Oldie but a Goodie

Posted on 25 November 2015 by Keith Barrington

I discovered several months ago that one of my older presentations is very difficult to get on-line. It seems that at some point, when this article, Barrington K, Finer N. The natural history of the appearance of apnea of prematurity. Pediatr … Continue reading →

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The last nail in the coffin of permissive hypercapnia?

Posted on 24 November 2015 by Keith Barrington

Thome UH, et al. Permissive hypercapnia in extremely low birthweight infants (PHELBI): a randomised controlled multicentre trial. Lancet Respir Med. 2015;3(7):534-43. This German multi-center trial randomized infants 400 to 1000 g birth weight to 2 different CO2 target ranges. The … Continue reading →

Posted in Neonatal Research | Tagged , | 1 Comment