Tag Archives: Randomized Controlled Trials

Early steroids to prevent Chronic Lung Disease; give them directly into the lungs?

Posted on 16 October 2015 by Keith Barrington

Bassler D, et al. Early Inhaled Budesonide for the Prevention of Bronchopulmonary Dysplasia. New England Journal of Medicine. 2015;373(16):1497-506. One of those ongoing trials that we have been awaiting the results of has just been published. The NEUROSIS trial was a … Continue reading →

Posted in Neonatal Research | Tagged , , | 4 Comments

At least they weren’t worse off.

Posted on 14 October 2015 by Keith Barrington

Fever is a frequent response to infection. The inflammatory response to invading organisms often leads to a febrile reaction, which many have suggested is an adaptive response, that might actually have an evolutionary advantage, and improve survival from serious infections. Of course … Continue reading →

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Many unethical pain studies in newborns

Posted on 23 September 2015 by Keith Barrington

Carlo Bellieni and Celeste Johnston (Conflict of Interest flag, I have collaborated with both of them) have just reviewed a couple of recent years research of analgesic interventions in the newborn. Of 46 randomized studies of painful procedures, 70% had … Continue reading →

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Lower oxygen resuscitation for preterms?

Posted on 15 September 2015 by Keith Barrington

A new publication from a group of us in the CNN, suggests that the answer to that query is ‘not so fast’. Rabi Y, Lodha A, Soraisham A, Singhal N, Barrington K, Shah PS, et al. Outcomes of preterm infants following … Continue reading →

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Re-re-re-visited (delayed cord clamping of course)

Posted on 5 June 2015 by Keith Barrington

I received 2 comments about the last posting re: DCC. The way I set up this blog the comments aren’t necessarily very obvious, especially if you visit the home page rather than following a link to the individual posting. So I … Continue reading →

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Delayed Cord Clamping re-re-visited

Posted on 4 June 2015 by Keith Barrington

I have been trying to develop some sort of protocol for babies in our center, so I have been reading in some detail the studies about very preterm births and cord clamping that are in the literature. It seems from … Continue reading →

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Cord milking/delayed clamping at the 2015 PAS-meeting

Posted on 19 May 2015 by Keith Barrington

I have tried to go through the abstracts from PAS to find those that had new information, from controlled trials, about the efficacy and safety of cord milking and/or delayed clamping. Mercer and the group from Rhode Island presented the … Continue reading →

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Delayed cord clamping or cord milking for the very preterm newborn… or both?

Posted on 18 May 2015 by Keith Barrington

What should we be doing, given the current state of the evidence, for the very preterm neonate? I think the evidence is now pretty clear that full-term babies have benefits, and no significant harm, from delayed cord clamping, which has … Continue reading →

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Neonatal Updates

Posted on 26 April 2015 by Keith Barrington

There’s been a lot of good stuff published recently, so time for a couple of Neonatal Updates. First the most recent (May) issue of the Archives Fetal and Neonatal edition was packed with interesting publications.(including 2 I have already blogged … Continue reading →

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Off-label NO: No… or Yes?

Posted on 8 April 2015 by Keith Barrington

Recent articles about off-label use of inhaled Nitric Oxide (iNO) in the preterm infant shows that such use is : a. extremely variable from one center to another, (Truog WE, et al. Inhaled nitric oxide usage in preterm infants in … Continue reading →

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