Tag Archives: Randomized Controlled Trials

PAS 2018 No2: let’s STOP-BPD

Posted on 10 May 2018 by Keith Barrington

The STOP-BPD trial was a multicenter trial from Holland, (registered as NTR2768) over 180 babies were randomized to each arm of this trial, they were <30 weeks or less than 1250 g at birth, and were still ventilated at 2 … Continue reading →

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PAS 2018 No1: SAIL away (and another mention by a science journalist).

Posted on 9 May 2018 by Keith Barrington

For some reason there is a small epidemic (n=2, that’s a pico-epidemic) of articles about probiotics and necrotising enterocolitis this year in the mainstream press. I was interviewed, and I am mentioned again, in this article on the NOVA “next” … Continue reading →

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Regular universal antibiotics to reduce infant mortality?

Posted on 3 May 2018 by Keith Barrington

This (Keenan JD, et al. Azithromycin to Reduce Childhood Mortality in Sub-Saharan Africa. The New England journal of medicine. 2018;378(17):1583-92 Open Access) is a new multicenter cluster randomized trial of giving all infants in a community regular azithromycin. If that … Continue reading →

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Too much oxygen is bad for adults too!

Posted on 2 May 2018 by Keith Barrington

The systematic review of the neonatal oxygen saturation targeting trials Askie LM, et al. Effects of targeting lower versus higher arterial oxygen saturations on death or disability in preterm infants. Cochrane database of systematic reviews (Online). 2017;4:Cd011190. confirmed the increase … Continue reading →

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Its now or… later? A good question to ask ELVIS.

Posted on 19 April 2018 by Keith Barrington

This study probably wins the prize for the best trial name in neonatal history, the Early or Late Ventricular Intervention Study, ELVIS. de Vries LS, et al. Treatment thresholds for intervention in posthaemorrhagic ventricular dilation: a randomised controlled trial. Archives … Continue reading →

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Disseminated Intravascular Coagulation, does it make you feel like a DIC?

Posted on 4 April 2018 by Keith Barrington

Influenza is crap. Especially when you get it even though you have had the vaccine! The break in blog posts has been due to an assortment of viral illnesses, culminating in the “flu” and then followed by spring break, followed … Continue reading →

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Inhaled Steroids to Prevent BPD? Think again… again!

Posted on 16 January 2018 by Keith Barrington

The NEUROSIS trial that I discussed in my previous post has, among other published trials, most in common with the trial by Nakamura published in 2016. Nakamura T, et al. Early inhaled steroid use in extremely low birthweight infants: a … Continue reading →

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Inhaled steroids to prevent BPD? Think again…

Posted on 15 January 2018 by Keith Barrington

The NEUROSIS trial was a high quality trial of inhaled budesonide started before 12 hours in extremely preterm infants (23 to <28 weeks gestation) receiving positive pressure respiratory support. The primary outcome of the trial was survival without needing oxygen … Continue reading →

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The last word on delayed cord clamping in the preterm? Part 2.

Posted on 8 November 2017 by Keith Barrington

I mentioned the second trial I wanted to discuss at the beginning of part 1. Duley L, et al. Randomised trial of cord clamping and initial stabilisation at very preterm birth. Archives of disease in childhood Fetal and neonatal edition. … Continue reading →

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The last word on delayed cord clamping for preterms? Part 1.

Posted on 7 November 2017 by Keith Barrington

The APTS (Australian placental transfusion study) trial has just appeared on line. This was a high-quality multicenter, international RCT of immediate cord clamping (less than 10 seconds) compared to delayed clamping (60 seconds) for babies born less than 32 weeks … Continue reading →

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