Tag Archives: Necrotising Enterocolitis

Necrotizing Enterocolitis: manipulating the microbiome, part 1

Posted on 6 May 2016 by Keith Barrington

Some very interesting recent publications about NEC, so I will post a multi-part bumper posting. The first has just been published (in tomorrow’s Lancet) Warner BB, et al. Gut bacteria dysbiosis and necrotising enterocolitis in very low birthweight infants: a prospective … Continue reading →

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PPIs are toxic

Posted on 4 October 2015 by Keith Barrington

PPIs could mean “public-private initiatives” which are highly toxic, as recent experience in the UK and in Quebec has shown, but in this case I mean proton pump inhibitors. Stark CM, Nylund CM. Side Effects and Complications of Proton Pump … Continue reading →

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Prebiotics, Probiotics and the microbiome

Posted on 2 October 2015 by Keith Barrington

A series of interesting recent articles: Yang J, et al. Application of Laser Capture Microdissection and 16S rRNA Gene Polymerase Chain Reaction in the Analysis of Bacteria Colonizing the Intestinal Tissue of Neonates With Necrotizing Enterocolitis. Pediatr Infect Dis J. … Continue reading →

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Do Blood transfusions trigger NEC? This month the answer is no.

Posted on 16 September 2015 by Keith Barrington

OK, not exactly this month, but “towards the end of last year” wouldn’t have been as good a title. Three case-control studies, with some differences in design and implementation, but all 3 with the same result, no evidence that red … Continue reading →

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NICUs are working better: still room for improvement.

Posted on 11 September 2015 by Keith Barrington

As NICUs have become more effective, any proportional incremental improvements will necessarily get smaller, so larger and larger datasets will be needed to show any trends. The NICHD has just published data about survival and major acute morbidities among extremely … Continue reading →

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Re-re-re-visited (delayed cord clamping of course)

Posted on 5 June 2015 by Keith Barrington

I received 2 comments about the last posting re: DCC. The way I set up this blog the comments aren’t necessarily very obvious, especially if you visit the home page rather than following a link to the individual posting. So I … Continue reading →

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Genetic variants and NEC risk

Posted on 19 May 2015 by Keith Barrington

This post is out of my usual comfort zone, but I thought I’d write about it as it is fascinating, and might lead to something clinical. I don’t understand any of the lab methodology of this study, except to say … Continue reading →

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Delayed cord clamping or cord milking for the very preterm newborn… or both?

Posted on 18 May 2015 by Keith Barrington

What should we be doing, given the current state of the evidence, for the very preterm neonate? I think the evidence is now pretty clear that full-term babies have benefits, and no significant harm, from delayed cord clamping, which has … Continue reading →

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What is the news about probiotics?

Posted on 9 March 2015 by Keith Barrington

A few things have been happening recently: first of all, the big news was that Solgar recalled ABCDophilus as a result of some contamination of the product. As many of you will probably know, there was fungal contamination of the … Continue reading →

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Feeding and NEC

Posted on 14 November 2014 by Keith Barrington

Necrotizing Enterocolitis remains a devastating disease. One of the major causes of mortality in Very Low Birth Weight Infants, it often strikes when babies are starting to do well. Because it is relatively unpredictable, observational studies are potentially useful, but can … Continue reading →

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