PPIs could mean “public-private initiatives” which are highly toxic, as recent experience in the UK and in Quebec has shown, but in this case I mean proton pump inhibitors.
Stark CM, Nylund CM. Side Effects and Complications of Proton Pump Inhibitors: A Pediatric Perspective. The Journal of pediatrics. 2015. This excellent and complete review of PPI toxicities has just been published.
Many people seem to think they are safe, and there has been an explosion in their use in the newborn, with practically no supportive data.
PPIs increase :
GI infections (including clostridia)
Upper respiratory infections
Lower respiratory infections
Gastric Fundal Polyps
Malabsorption of calcium
Malabsorption of magnesium
Probably malabsorption of iron and some vitamins
Acute interstitial nephritis
and, of course, Necrotising Enterocolitis.
You should really have good evidence that gastric acid secretion is causing your baby’s problems before prescribing these toxins.