Tag Archives: steroids

Death or oxygen, which is worse?

Posted on 27 February 2019 by Keith Barrington

We have a big problem in neonatal research. We have constructed composite outcomes that have become the “standard of design”, but are not of much use for anyone. Because we are, rightly, concerned that death and other diagnoses may be … Continue reading →

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PAS 2018 No2: let’s STOP-BPD

Posted on 10 May 2018 by Keith Barrington

The STOP-BPD trial was a multicenter trial from Holland, (registered as NTR2768) over 180 babies were randomized to each arm of this trial, they were <30 weeks or less than 1250 g at birth, and were still ventilated at 2 … Continue reading →

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Inhaled Steroids to Prevent BPD? Think again… again!

Posted on 16 January 2018 by Keith Barrington

The NEUROSIS trial that I discussed in my previous post has, among other published trials, most in common with the trial by Nakamura published in 2016. Nakamura T, et al. Early inhaled steroid use in extremely low birthweight infants: a … Continue reading →

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Inhaled steroids to prevent BPD? Think again…

Posted on 15 January 2018 by Keith Barrington

The NEUROSIS trial was a high quality trial of inhaled budesonide started before 12 hours in extremely preterm infants (23 to <28 weeks gestation) receiving positive pressure respiratory support. The primary outcome of the trial was survival without needing oxygen … Continue reading →

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Short courses of Steroids are hazardous… even for adults!

Posted on 25 April 2017 by Keith Barrington

There were a number of things that surprised me in this study. the first was how many adults get short courses of oral steroids in the USA (and for all I know in other countries too). Waljee AK, et al. … Continue reading →

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Early low dose hydrocortisone seems to not affect medium term development; PREMILOC outcomes at 22 months.

Posted on 18 April 2017 by Keith Barrington

The PREMILOC trial was a multi-center RCT of hydrocortisone, 0.5mg/kg twice per day for 7 days followed by 0.5 mg/kg per day for 3 days, given starting within 24 hours of age to infants of 24 to less than 28 … Continue reading →

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Inhaled steroids for BPD?

Posted on 12 December 2016 by Keith Barrington

In a recent post I promoted a new Barrington rule for meta-analysis (it probably already existed somewhere but I am claiming priority anyway, it’s a “post-truth” kind of thing). The rule was that in a systematic review you shouldn’t pool … Continue reading →

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Antenatal Steroids closer to term?

Posted on 4 November 2016 by Keith Barrington

A new systematic review in the BMJ (Saccone G, Berghella V. Antenatal corticosteroids for maturity of term or near term fetuses: systematic review and meta-analysis of randomized controlled trials. BMJ. 2016;355:i5044) includes 3 studies which examined the use of antenatal … Continue reading →

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Inhaled steroids to prevent BPD, another trial.

Posted on 12 April 2016 by Keith Barrington

This time from Japan, Nakamura T, et al. Early inhaled steroid use in extremely low birthweight infants: a randomised controlled trial. Archives of Disease in Childhood – Fetal and Neonatal Edition. 2016. 211 babies with a birth weight less than 1000 … Continue reading →

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Early low dose systemic hydrocortisone to prevent death or chronic lung disease? Hold on a bit.

Posted on 11 March 2016 by Keith Barrington

An important high quality trial has just been published, it has taken me a bit longer than usual to process the new info. Among other reasons a nice review was posted on the “other neonatal blog“, but I wanted to … Continue reading →

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