Tag Archives: mortality

BOOST-II long term outcomes

Posted on 16 February 2016 by Keith Barrington

The long-running epic of the oxygen saturation targeting trials is nearing completion. This publication of the joint results of the Australia and UK trials now includes the primary outcome for the trials, the combined rate of death or “disability”. Australia … Continue reading →

Posted in Neonatal Research | Tagged , , , | 1 Comment

The best outcome variable for very preterm newborns?

Posted on 27 November 2015 by Keith Barrington

Death or ‘neurodevelopmental impairment’ (NDI) as a combined outcome has become a sort of de facto standard as the primary outcome for neonatal clinical trials. Because many very preterm infants have developmental delay, intellectual and learning difficulties, and some have … Continue reading →

Posted in Clinical Practice Guidelines, Neonatal Research | Tagged , , , | 1 Comment

Endotracheal intubation is hazardous

Posted on 15 November 2015 by Keith Barrington

Which is no surprise, I hope, to any of us. Neil Finer has been a leader in the field of recognizing and quantifying the adverse physiologic effects of endotracheal intubation, and of finding ways to reduce those effects using premedication. … Continue reading →

Posted in Neonatal Research | Tagged , , | 1 Comment

Late Surfactant may not be effective, probably.

Posted on 29 October 2015 by Keith Barrington

A large multi-center trial (n=511) led by Roberta Ballard has just been published. (Ballard RA, et al. Randomized Trial of Late Surfactant Treatment in Ventilated Preterm Infants Receiving Inhaled Nitric Oxide. J Pediatr 2015.) In this trial infants had similar … Continue reading →

Posted in Neonatal Research | Tagged , , , , | Leave a comment

Another extremely flawed guideline on periviable deliveries

Posted on 26 October 2015 by Keith Barrington

Oh Dear, here we go again… This is a joint statement from ACOG and the SMFM. There is some good in here, but you’d think they could at least get the facts right. “Delivery before 23 weeks of gestation typically … Continue reading →

Posted in Clinical Practice Guidelines | Tagged , , , | 7 Comments

What if 5 were the magic number?

Posted on 5 October 2015 by Keith Barrington

Our weeks are made of 7 days. An entirely arbitrary unit of measurement, based on an idea that 7 is magical, so there are 7 continents, 7 seas, 7 days of the week. Or maybe because you can easily divide … Continue reading →

Posted in Neonatal Research | Tagged , , | 4 Comments

Holland is changing

Posted on 4 October 2015 by Keith Barrington

A new article from the Groningen group, plus Annie Janvier. Koper JF, et al. Dutch neonatologists have adopted a more interventionist approach to neonatal care. Acta Paediatr. 2015;104(9):888-93. It documents changes in their delivery room and NICU in end-of life practices between … Continue reading →

Posted in Neonatal Research | Tagged | Leave a comment

NRP Works!

Posted on 23 September 2015 by Keith Barrington

When the neonatal resuscitation program was first introduced I think many of us had mixed feelings. I was concerned that some of the initial recommendations were opinion-based rather than evidence-based  (and they weren’t all consistent with my opinions, which are … Continue reading →

Posted in Neonatal Research | Tagged , | 1 Comment

Lower oxygen resuscitation for preterms?

Posted on 15 September 2015 by Keith Barrington

A new publication from a group of us in the CNN, suggests that the answer to that query is ‘not so fast’. Rabi Y, Lodha A, Soraisham A, Singhal N, Barrington K, Shah PS, et al. Outcomes of preterm infants following … Continue reading →

Posted in Neonatal Research | Tagged , , , | 4 Comments

NICUs are working better: still room for improvement.

Posted on 11 September 2015 by Keith Barrington

As NICUs have become more effective, any proportional incremental improvements will necessarily get smaller, so larger and larger datasets will be needed to show any trends. The NICHD has just published data about survival and major acute morbidities among extremely … Continue reading →

Posted in Neonatal Research | Tagged , , , , | Leave a comment