For another project, which I will explain later, I have been trying to find recent large multicentre trials in very preterm babies. I searched PubMed for “Randomized Controlled Trial’, and “Multicentre study”, then filtered by Human and Newborn and Preterm and just looked at the last 10 years. So far here is the impressive list of Acronyms for the trials in approximately reverse chronological order: See how many you can recognize! There will be a prize for anyone who gets them all!
SAIL, ETTNEO, MOBYDICK, LIFT, PENUT, SIFT, PREMOD2, RAINBOW, CORD PILOT, STOP-BPD, PLANET-2, PROPREMS, Reduce-ROP, CPAP-wean, NEUROSIS, HUMID, NEWNO, APTS, N3RO, PHELBI, PIPS, rhEPO, NEON, PREMILOC, BOOST2 UK, BOOST2 Aus, COT, SafeBoosc2, TENS, COIN, SUPPORT, TIPP, CAP, PINT, ELFIN, ADEPT, STOP-ROP, ETROP, BEAT-ROP, CRYO-ROP, VON-DR, INIS
The prize I have in my mind is my admiration! There were one or two that I had to search hard to find the acronym, and there are a couple of trials which aren’t in the list because I could not find one at all (such as the budesonide/surfactant trial).
The reason I have been trying to list all the recent large trials is to see if I can develop a database of evidence-based treatments for the most immature babies that we treat, of 22, 23 and 24 weeks gestation. The physiological immaturity of these babies is so extreme that for some interventions it is likely that their response may be different. I am searching to see which trials included such immature babies, and whether there are any data presented for infants under 25 weeks. So far… not much, but when I complete the search I will write it up as a publication, and let you all know on this blog.
If any readers know of a large RCT which included extremely immature babies and which is not on the list, please let me know, especially if data are presented for the gestational age stratum <25 weeks.