Frozen poop sounds much more palatable

Fecal transplants are effective in treatment of persistent clostridium difficile infections. The publication showing that, in the small RCT published in the PNEJM, was remarkable in the pre-screened donors who were ready and available to produce a “donation” on demand.

This new study (Youngster I, Russell GH, Pindar C, Ziv-Baran T, Sauk J, Hohmann EL. Oral, Capsulized, Frozen Fecal Microbiota Transplantation for Relapsing Clostridium difficile Infection. JAMA. 2014;312(17):1772-8.) takes poop from screened donors and freeze dries it and puts it in capsules: 70% of the small group of patients resolved their diarrhoea after a single treatment. The others almost all resolved after repeat treatment. This way of treating has the advantage of not needing a list of on-call volunteers, and not needing to pass a tube into the intestine. It has the disadvantage that if you forget, and bite down on the capsule….

About Keith Barrington

I am a neonatologist and clinical researcher at Sainte Justine University Health Center in Montréal
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