Tag Archives: Randomized Controlled Trials

CPAP or PAF?

Posted on 7 September 2012 by Keith Barrington

Several devices marketed as CPAP devices are not in fact devices designed to deliver constant pressure. For example the Infant Flow device, widely used in NICUs, delivers a constant flow into its circuit, but there is no mechanism to respond to changes … Continue reading →

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Weekly Updates #3

Posted on 8 August 2012 by Keith Barrington

A few new publications (I know it’s not quite weekly, but I am on vacation!): Nguyen TP, Amon E, Al-Hosni M, Gavard JA, Gross G, Myles TD: “Early” versus “late” 23-week infant outcomes. Am J Obstet Gynecol 2012(0). Not too … Continue reading →

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Improving outcomes of Preterm Infants, early post-discharge intervention programs

Posted on 8 August 2012 by Keith Barrington

The history of early intervention programs is rather mixed. Do they actually help to improve outcomes? The most recent cochrane review was published in 2007 by the amazingly productive Lex Doyle and his colleagues, and was followed by an updated review … Continue reading →

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Trying to improve outcomes of preterm infants

Posted on 17 July 2012 by Keith Barrington

Two recent RCTs in high risk newborns of things I would never have thought of. The first is a trial of Estradiol and Progesterone supplementation (Trotter A, Steinmacher J, Kron M, Pohlandt F. Neurodevelopmental Follow-Up at Five Years Corrected Age … Continue reading →

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How to Improve Ventilation of Babies during Resuscitation

Posted on 9 July 2012 by Keith Barrington

So how do we improve resuscitation of newborn babies, and specifically of the preterm? Although I am a “true believer (TM)”  in evidence based practice it is obvious that every individual change in neonatal practice will not (and cannot) be … Continue reading →

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Does the way we feed babies affect Necrotizing Enterocolitis?

Posted on 2 July 2012 by Keith Barrington

There is a widespread feeling that the method of introduction and advancement of feeds affects the frequency of necrotizing enterocolitis (known as NEC). Multiple observational studies have been published that seem to support this fear. However when we search for randomized controlled trials comparing feeding practices … Continue reading →

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What next for birth asphyxia?

Posted on 27 June 2012 by Keith Barrington

Now that therapeutic hypothermia has been proven effective and safe for infants with Hypoxic Ischemic Encephalopathy, one might ask what next? We still are not sure if it is of any value to cool infants after 6 hours of age, … Continue reading →

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When to deliver twins?

Posted on 21 June 2012 by Keith Barrington

A new RCT from Australia randomized 235 mothers carrying twins to be either delivered at 37 weeks gestation, or allowed to continue for at least another week (Dodd J, Crowther C, Haslam R, Robinson J, for the Twins Timing of … Continue reading →

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Long Term outcomes after Therapeutic Hypothermia for HIE

Posted on 13 June 2012 by Keith Barrington

Two new publications from multicenter trials of hypothermia as a treatment for post-asphyxial encephalopathy. The first from the NICHD network, and the whole body cooling study led by Seetha Shankaran. They examined the children and performed IQ testing at 6 to 7 … Continue reading →

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Fluid Restricting Babies: Part 2

Posted on 30 May 2012 by Keith Barrington

While I am on a roll… Fluid restriction as a means of treating babies with BPD makes no sense. It is also unsupported by any literature. I think this practice may have arisen because diuretics are given to infants with BPD (don’t get … Continue reading →

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