Tag Archives: Randomized Controlled Trials

More about reflux: anti-acid medications may also be toxic placebos

Posted on 28 November 2012 by Keith Barrington

While I am still finalizing my long overdue chapter on gastro-esophageal reflux (sorry Sanjay if you are reading this, it is on its way, honestly) I have been reviewing the data on acid blockade as a potential treatment. Probably the … Continue reading →

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Premedication for Intubation

Posted on 13 November 2012 by Keith Barrington

There are several studies of what premedication should be used for intubation of the newborn. An analgesic or anesthetic agent should be given in to reduce pain, which also reduces the adverse physiologic consequences of the intubation. Several studies of … Continue reading →

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Feeding patterns and NEC

Posted on 6 November 2012 by Keith Barrington

I have discussed before evidence about whether the pattern of introduction or advancement of feeds affects NEC.  I noted that there is only one out of a large number of trials of feeding introduction and advancement which has shown an … Continue reading →

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Chloride is toxic

Posted on 29 October 2012 by Keith Barrington

I think we have given too little attention to the nature of the crystalloid solutions we use. Not just in neonatology, but apparently in the adult ICU also,  (Yunos NM, Bellomo R, Hegarty C, Story D, Ho L, Bailey M: Association between … Continue reading →

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Glutamine supplementation, just when you thought it was solved…

Posted on 24 October 2012 by Keith Barrington

Glutamine is one of the most abundant amino acids in our bodies, but there is relatively little in TPN as it is poorly soluble. During the first few days of limited enteral nutrition preterm babies receive little glutamine from any … Continue reading →

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Early Detection of Sepsis in the NICU

Posted on 16 October 2012 by Keith Barrington

This came out before I started my blog, but think it is very important. I was reminded that I had never mentioned it on this blog when I met Joseph Randall Moorman at the airport on the way back from … Continue reading →

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Fresh! New! but not any better.

Posted on 11 October 2012 by Keith Barrington

A new multicenter RCT in preterm infants has just been published. The ARIPI trial which was led by Dean Fergusson from Ottawa and included our NICU as one of the sites (Christian Lachance was our local lead investigator and is … Continue reading →

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Probiotics: enough is enough

Posted on 9 October 2012 by Keith Barrington

At the EAPS meeting in Istanbul, the Proprems trial results were just presented. Now this has not yet been subject to full peer-review, but as a report of a large multicenter RCT it is not likely that their main findings … Continue reading →

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Domperidone for GE reflux; toxic and worse than placebo!

Posted on 6 October 2012 by Keith Barrington

As mentioned in a previous post, to get cisapride for a patient in Canada, you have to contact Health Canada for special permission through the Special Access Program. The last time that I am aware of someone asking Health Canada for special … Continue reading →

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Improving Nutrition in the very Preterm; more protein?

Posted on 1 October 2012 by Keith Barrington

A new study published in Pediatrics looked at the question in the title of this post. Moya F, Sisk PM, Walsh KR, Berseth CL: A new liquid human milk fortifier and linear growth in preterm infants. Pediatrics 2012.  This was a … Continue reading →

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