Tag Archives: Randomized Controlled Trials

When to deliver twins?

Posted on 21 June 2012 by Keith Barrington

A new RCT from Australia randomized 235 mothers carrying twins to be either delivered at 37 weeks gestation, or allowed to continue for at least another week (Dodd J, Crowther C, Haslam R, Robinson J, for the Twins Timing of … Continue reading →

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Long Term outcomes after Therapeutic Hypothermia for HIE

Posted on 13 June 2012 by Keith Barrington

Two new publications from multicenter trials of hypothermia as a treatment for post-asphyxial encephalopathy. The first from the NICHD network, and the whole body cooling study led by Seetha Shankaran. They examined the children and performed IQ testing at 6 to 7 … Continue reading →

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Fluid Restricting Babies: Part 2

Posted on 30 May 2012 by Keith Barrington

While I am on a roll… Fluid restriction as a means of treating babies with BPD makes no sense. It is also unsupported by any literature. I think this practice may have arisen because diuretics are given to infants with BPD (don’t get … Continue reading →

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Fluid Restricting Babies

Posted on 29 May 2012 by Keith Barrington

A study published online first in the Journal of Pediatrics questions a common practice, the practice of fluid restricting babies who have a patent ductus arteriosus. De Buyst J, Rakza T, Pennaforte T, Johansson AB, Storme L: Hemodynamic Effects of … Continue reading →

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Septic Shock

Posted on 25 May 2012 by Keith Barrington

This study is not neonatal at all, not even pediatric, but I think it is really important. Ranieri VM, Thompson BT, Barie PS, Dhainaut JF, Douglas IS, Finfer S, et al. Drotrecogin Alfa (Activated) in Adults with Septic Shock. N … Continue reading →

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Weaning from CPAP in preterm babies

Posted on 23 May 2012 by Keith Barrington

There have been very few studies of how to wean babies from CPAP, even though it is something we do all the time. A recent tendency, which seems to have arisen without any supportive data, and which never made much sense … Continue reading →

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Nutrition of very preterm babies

Posted on 11 May 2012 by Keith Barrington

There is a ‘growing’ feeling that we don’t give enough protein to our preterm infants, especially during the enteral phases of nutrition. Fortified maternal breast milk use is associated with lower overall rates of weight gain, despite all its benefits. … Continue reading →

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Pain relief for intramuscular injections

Posted on 10 May 2012 by Keith Barrington

Sometimes we can’t avoid giving an IM injection, even though they are painful. Some vaccines should be given IM, and the routine needle in the thigh of every baby for vitamin K is a rite of passage, that has become standard everywhere. … Continue reading →

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Pain relief and retinopathy screening, part 2.

Posted on 9 May 2012 by Keith Barrington

My good friend Gene Dempsey (a neonatologist and clinical researcher in Cork) reminded me of their trial published in 2010, and suggested that the title of my previous post may be misleading. I guess I really don’t want readers to think that … Continue reading →

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Preventing Prematurity

Posted on 8 May 2012 by Keith Barrington

We’ve known for a while that progesterones can reduce prematurity in certain situations. Intramuscular 17 hydroxy progesterone caproate reduces prematurity in women who have had a previous premature baby. (Meis’s article link below) Now a systematic review of intravaginal progesterone … Continue reading →

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