Tag Archives: Randomized Controlled Trials

Trying to improve outcomes of preterm infants

Posted on 17 July 2012 by Keith Barrington

Two recent RCTs in high risk newborns of things I would never have thought of. The first is a trial of Estradiol and Progesterone supplementation (Trotter A, Steinmacher J, Kron M, Pohlandt F. Neurodevelopmental Follow-Up at Five Years Corrected Age … Continue reading →

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How to Improve Ventilation of Babies during Resuscitation

Posted on 9 July 2012 by Keith Barrington

So how do we improve resuscitation of newborn babies, and specifically of the preterm? Although I am a “true believer (TM)”  in evidence based practice it is obvious that every individual change in neonatal practice will not (and cannot) be … Continue reading →

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Does the way we feed babies affect Necrotizing Enterocolitis?

Posted on 2 July 2012 by Keith Barrington

There is a widespread feeling that the method of introduction and advancement of feeds affects the frequency of necrotizing enterocolitis (known as NEC). Multiple observational studies have been published that seem to support this fear. However when we search for randomized controlled trials comparing feeding practices … Continue reading →

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What next for birth asphyxia?

Posted on 27 June 2012 by Keith Barrington

Now that therapeutic hypothermia has been proven effective and safe for infants with Hypoxic Ischemic Encephalopathy, one might ask what next? We still are not sure if it is of any value to cool infants after 6 hours of age, … Continue reading →

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When to deliver twins?

Posted on 21 June 2012 by Keith Barrington

A new RCT from Australia randomized 235 mothers carrying twins to be either delivered at 37 weeks gestation, or allowed to continue for at least another week (Dodd J, Crowther C, Haslam R, Robinson J, for the Twins Timing of … Continue reading →

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Long Term outcomes after Therapeutic Hypothermia for HIE

Posted on 13 June 2012 by Keith Barrington

Two new publications from multicenter trials of hypothermia as a treatment for post-asphyxial encephalopathy. The first from the NICHD network, and the whole body cooling study led by Seetha Shankaran. They examined the children and performed IQ testing at 6 to 7 … Continue reading →

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Fluid Restricting Babies: Part 2

Posted on 30 May 2012 by Keith Barrington

While I am on a roll… Fluid restriction as a means of treating babies with BPD makes no sense. It is also unsupported by any literature. I think this practice may have arisen because diuretics are given to infants with BPD (don’t get … Continue reading →

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Fluid Restricting Babies

Posted on 29 May 2012 by Keith Barrington

A study published online first in the Journal of Pediatrics questions a common practice, the practice of fluid restricting babies who have a patent ductus arteriosus. De Buyst J, Rakza T, Pennaforte T, Johansson AB, Storme L: Hemodynamic Effects of … Continue reading →

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Septic Shock

Posted on 25 May 2012 by Keith Barrington

This study is not neonatal at all, not even pediatric, but I think it is really important. Ranieri VM, Thompson BT, Barie PS, Dhainaut JF, Douglas IS, Finfer S, et al. Drotrecogin Alfa (Activated) in Adults with Septic Shock. N … Continue reading →

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Weaning from CPAP in preterm babies

Posted on 23 May 2012 by Keith Barrington

There have been very few studies of how to wean babies from CPAP, even though it is something we do all the time. A recent tendency, which seems to have arisen without any supportive data, and which never made much sense … Continue reading →

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