Tag Archives: Randomized Controlled Trials

Chloride is toxic

Posted on 29 October 2012 by Keith Barrington

I think we have given too little attention to the nature of the crystalloid solutions we use. Not just in neonatology, but apparently in the adult ICU also,  (Yunos NM, Bellomo R, Hegarty C, Story D, Ho L, Bailey M: Association between … Continue reading →

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Glutamine supplementation, just when you thought it was solved…

Posted on 24 October 2012 by Keith Barrington

Glutamine is one of the most abundant amino acids in our bodies, but there is relatively little in TPN as it is poorly soluble. During the first few days of limited enteral nutrition preterm babies receive little glutamine from any … Continue reading →

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Early Detection of Sepsis in the NICU

Posted on 16 October 2012 by Keith Barrington

This came out before I started my blog, but think it is very important. I was reminded that I had never mentioned it on this blog when I met Joseph Randall Moorman at the airport on the way back from … Continue reading →

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Fresh! New! but not any better.

Posted on 11 October 2012 by Keith Barrington

A new multicenter RCT in preterm infants has just been published. The ARIPI trial which was led by Dean Fergusson from Ottawa and included our NICU as one of the sites (Christian Lachance was our local lead investigator and is … Continue reading →

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Probiotics: enough is enough

Posted on 9 October 2012 by Keith Barrington

At the EAPS meeting in Istanbul, the Proprems trial results were just presented. Now this has not yet been subject to full peer-review, but as a report of a large multicenter RCT it is not likely that their main findings … Continue reading →

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Domperidone for GE reflux; toxic and worse than placebo!

Posted on 6 October 2012 by Keith Barrington

As mentioned in a previous post, to get cisapride for a patient in Canada, you have to contact Health Canada for special permission through the Special Access Program. The last time that I am aware of someone asking Health Canada for special … Continue reading →

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Improving Nutrition in the very Preterm; more protein?

Posted on 1 October 2012 by Keith Barrington

A new study published in Pediatrics looked at the question in the title of this post. Moya F, Sisk PM, Walsh KR, Berseth CL: A new liquid human milk fortifier and linear growth in preterm infants. Pediatrics 2012.  This was a … Continue reading →

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More sweetness, some light?

Posted on 27 September 2012 by Keith Barrington

The latest NEJM has an article addressing an issue that I recently posted about, glucose control in the critically ill. This study was in 980 children less than 3 years of age who had undergone cardiac surgery in 2 centers … Continue reading →

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Sweet!

Posted on 24 September 2012 by Keith Barrington

Very immature babies often become hyperglycemic during the first few days of life. How to respond (or prevent) this has been uncertain. One problem in deciding on the best course of action is the multiple possible approaches that need to … Continue reading →

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Analgesia and co-bedding or kangaroo care

Posted on 11 September 2012 by Keith Barrington

Campbell-Yeo ML, Johnston CC, Joseph KS, Feeley N, Chambers CT, Barrington KJ: Cobedding and Recovery Time After Heel Lance in Preterm Twins: Results of a Randomized Trial. Pediatrics 2012. If I might be permitted a little self-promotion… this new study … Continue reading →

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