Tag Archives: Randomized Controlled Trials

Do Probiotics prevent C difficile?

Posted on 18 October 2013 by Keith Barrington

My recent post about Bayesian analysis was in part prompted by this trial, just published in the Lancet, but I never got back to discussing this trial, being distracted by other things, like actual work. Nearly 3000 adults were randomized … Continue reading →

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Feeding during PDA treatment

Posted on 15 October 2013 by Keith Barrington

Ron Clyman and a multicenter group have just published this DAFFII trial. Which is a rather tortuous light-hearted acronym for Ductus Arteriosus Feed or Fast with Indomethcain or Ibuprofen.   (Clyman R, Wickremasinghe A, Jhaveri N, Hassinger DC, Attridge JT, Sanocka … Continue reading →

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More extubation stuff

Posted on 11 October 2013 by Keith Barrington

Eduardo Banclari’s group have just published an RCT comparing success of extubation among 93 babies less than  1 kg birth weight who were put on low CPAP pressure (4 to 6) or high pressure (7 to 9 cm H2O). These were … Continue reading →

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High Flow Nasal Cannulae; finally learning about them

Posted on 11 October 2013 by Keith Barrington

The Melbourne group must get fed up of publishing important research, here is another in the PNEJM. Manley BJ, Owen LS, Doyle LW, Andersen CC, Cartwright DW, Pritchard MA, Donath SM, Davis PG: High-flow nasal cannulae in very preterm infants … Continue reading →

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Informed consent in the NICU

Posted on 26 September 2013 by Keith Barrington

I have watched most of the presentations at the OHRP meeting, so you don’t have to. Many of the critics of SUPPORT make the same mistaken assumption, that usual care in the NICU is to individualize oxygen saturation targets, I … Continue reading →

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Prebiotics, to support growth of Probiotics, and how to kill them

Posted on 25 September 2013 by Keith Barrington

Ishizeki S, Sugita M, Takata M, Yaeshima T: Effect of administration of bifidobacteria on intestinal microbiota in low-birth-weight infants and transition of administered bifidobacteria: A comparison between one-species and three-species administration. Anaerobe 2013, 23(0):38-44. In this study the investigators report 3 … Continue reading →

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C’est inSUPPORTable!

Posted on 19 September 2013 by Keith Barrington

A new publication about SUPPORT? Haven’t we heard enough? Well no, this is fascinating, although not entirely unexpected if you think about it. One of the 2 comparisons of the SUPPORT trial involved randomization to be either immediately intubated to receive surfactant, … Continue reading →

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What are the responsibilities of clinical researchers?

Posted on 18 September 2013 by Keith Barrington

One of the presentations at the OHRP hearings of the HHS was by George Annas, a JD who has an MPH (for those outside of north america that means he is a lawyer, but with a masters in public health). … Continue reading →

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Pluto, not just a planet anymore.

Posted on 11 September 2013 by Keith Barrington

Or should that be, not even a planet… One other thing I wanted to mention about the PLUTO trial is the entry criterion. The main entry criterion was the presence of clear lower urinary tract obstruction in a male fetus, … Continue reading →

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Who was Bayes, and what did he know about medical research?

Posted on 11 September 2013 by Keith Barrington

I don’t have much detail to answer the first question: he was an 18th century English mathematician who wrote something about probability, that was published after he died. That publication described something called Bayes’ theorem which is a way of … Continue reading →

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