Tag Archives: Randomized Controlled Trials

Preterm twins seem to care for one another

Posted on 14 January 2014 by Keith Barrington

There has been a lot of talk about co-bedding twins in the NICU, but relatively little research. I was involved in an RCT of co-bedding in preterm twins, looking at responses to painful stimuli (67 pars of twins were recruited). … Continue reading →

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The PDA, indomethacin and pulmonary hemorrhages.

Posted on 15 December 2013 by Keith Barrington

In a comment on a recent post, Martin Kluckow pointed out that they have just had published a moderately sized RCT. It was supposed to be larger, but intravenous indomethacin became unavailable, so they had to stop the trial. (Kluckow … Continue reading →

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Omega 3 containing lipid emulsions for the preterm: time for a large RCT

Posted on 11 December 2013 by Keith Barrington

A recent small RCT from Turkey, n=80 (Beken S, Dilli D, Fettah ND, Kabatas EU, Zenciroglu A, Okumus N: The influence of fish-oil lipid emulsions on retinopathy of prematurity in very low birth weight infants: A randomized controlled trial. Early … Continue reading →

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Probiotics work, they really, really, work! (And they are safe)

Posted on 22 November 2013 by Keith Barrington

The Proprems study that I have referred to a couple of times before has now been published. This was a multicenter RCT of a probiotic preparation in 1100 very preterm infants less than 1500 grams and less than 32 weeks. … Continue reading →

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GE Reflux… again

Posted on 22 November 2013 by Keith Barrington

Esomeprazole is one of the Proton pump inhibitors that is quite effective at reducing gastric acid production. This RCT of 51 infants (preterms to 1 month of age) randomized babies that had symptoms that were interpreted as being due to … Continue reading →

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Personalized Medicine in the NICU

Posted on 20 November 2013 by Keith Barrington

An article I wrote, with that title, as an open peer commentary in the American Journal of Bioethics has just appeared on-line. The first 50 people to click on the link at the bottom of this post below can get a free full … Continue reading →

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Palivizumab for late preterm infants, can we afford it?

Posted on 4 November 2013 by Keith Barrington

It is quite clear that palivizumab reduces the incidence of RSV disease, and probably also the severity, among those who still get it nevertheless. It is just as clear that it is extremely expensive. If RSV is likely to make … Continue reading →

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Registry Trials

Posted on 30 October 2013 by Keith Barrington

The latest PNEJM reports a large trial in adults (over 7000 patients randomized) in a very tasty trial, known as TASTE (Thrombus Aspiration in ST-Elevation Myocardial Infarction in Scandinavia). The trial was among patients who were undergoing coronary angiography and … Continue reading →

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Reducing BPD by Avoiding Intubation

Posted on 29 October 2013 by Keith Barrington

Sometimes more than one article gets published almost simultaneously on the same topic, sometimes with similar methodology. Two systematic reviews of the effects of trying to avoid or curtail endotracheal intubation in order to protect the lungs have just been … Continue reading →

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How to deliver CPAP

Posted on 25 October 2013 by Keith Barrington

Two almost simultaneous articles, one from the Melbourne group. One from Colm O’Donnell in Dublin who has worked with the Melbourne group in the past Kamlin COF, Schilleman K, Dawson JA, Lopriore E, Donath SM, Schmölzer GM, Walther FJ, Davis … Continue reading →

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