Tag Archives: Randomized Controlled Trials

More about mother’s voices

Posted on 26 February 2014 by Keith Barrington

When I first read this article I thought that the authors had rigged up a system to play music actually in the babies mouth, but I think I was wrong about that. Chorna OD, Slaughter JC, Wang L, Stark AR, … Continue reading →

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Does being ventilated hurt? It depends who you ask

Posted on 21 February 2014 by Keith Barrington

Ruth Guinsburg is a neonatologist in Sao Paulo who has been super-productive, especially in the area of pain control in the newborn. Her latest is an interesting comparison of how caregivers and parents rate pain in infants on ventilators. Elias … Continue reading →

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Yet more probiotic stuff

Posted on 14 February 2014 by Keith Barrington

Here is the other study of saccharomyces that I mentioned previously on this blog (Demirel G, Erdeve O, Celik IH, Dilmen U: Saccharomyces boulardii for prevention of necrotizing enterocolitis in preterm infants: A randomized, controlled study. Acta Paediatrica 2013) recently … Continue reading →

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If massage is so good, how come the research is so bad?

Posted on 5 February 2014 by Keith Barrington

I think its likely that massage therapy for the preterm infant has some benefits, unfortunately much of the research is under-powered, badly designed, inappropriately analyzed and overinterpreted. A case in point is a new study in Early Human Development, which … Continue reading →

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Preterm twins seem to care for one another

Posted on 14 January 2014 by Keith Barrington

There has been a lot of talk about co-bedding twins in the NICU, but relatively little research. I was involved in an RCT of co-bedding in preterm twins, looking at responses to painful stimuli (67 pars of twins were recruited). … Continue reading →

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The PDA, indomethacin and pulmonary hemorrhages.

Posted on 15 December 2013 by Keith Barrington

In a comment on a recent post, Martin Kluckow pointed out that they have just had published a moderately sized RCT. It was supposed to be larger, but intravenous indomethacin became unavailable, so they had to stop the trial. (Kluckow … Continue reading →

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Omega 3 containing lipid emulsions for the preterm: time for a large RCT

Posted on 11 December 2013 by Keith Barrington

A recent small RCT from Turkey, n=80 (Beken S, Dilli D, Fettah ND, Kabatas EU, Zenciroglu A, Okumus N: The influence of fish-oil lipid emulsions on retinopathy of prematurity in very low birth weight infants: A randomized controlled trial. Early … Continue reading →

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Probiotics work, they really, really, work! (And they are safe)

Posted on 22 November 2013 by Keith Barrington

The Proprems study that I have referred to a couple of times before has now been published. This was a multicenter RCT of a probiotic preparation in 1100 very preterm infants less than 1500 grams and less than 32 weeks. … Continue reading →

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GE Reflux… again

Posted on 22 November 2013 by Keith Barrington

Esomeprazole is one of the Proton pump inhibitors that is quite effective at reducing gastric acid production. This RCT of 51 infants (preterms to 1 month of age) randomized babies that had symptoms that were interpreted as being due to … Continue reading →

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Personalized Medicine in the NICU

Posted on 20 November 2013 by Keith Barrington

An article I wrote, with that title, as an open peer commentary in the American Journal of Bioethics has just appeared on-line. The first 50 people to click on the link at the bottom of this post below can get a free full … Continue reading →

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