Tag Archives: Randomized Controlled Trials

Sustained inflation during neonatal resuscitation? Not so fast…

Posted on 18 August 2016 by Keith Barrington

A sustained inflation at birth of an asphyxiated lamb which lasts 30 seconds leads to much more rapid restoration of heart rate and blood pressure than either conventional ventilation or a series of shorter sustained inflations of 5 seconds each. … Continue reading →

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Neonatal Updates: Recent Nutritional Publications part 2.

Posted on 16 August 2016 by Keith Barrington

Breast Milk and how to use it Colacci M, et al. Growth and Development in Extremely Low Birth Weight Infants After the Introduction of Exclusive Human Milk Feedings. American journal of perinatology. 2016(EFirst). This is a before and after study … Continue reading →

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Causes and Consequences of Bronchopulmonary Dysplasia

Posted on 21 June 2016 by Keith Barrington

Sullivan K, et al. The Association between Positive Tracheal Aspirate Cultures and Adverse Pulmonary Outcomes in Preterm Infants with Severe Bronchopulmonary Dysplasia. American journal of perinatology. 2016(EFirst).  This is an interesting study, with many limitations. 121 intubated VLBW preterm infants … Continue reading →

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Why didn’t erythropoietin improve the outcome of preterm babies?

Posted on 18 May 2016 by Keith Barrington

Because that is the result of a newly published RCT of erythropoietin (EPO) for neuroprotection of small preterm babies, no effect. Natalucci G, et al. Effect of Early Prophylactic High-Dose Recombinant Human Erythropoietin in Very Preterm Infants on Neurodevelopmental Outcome … Continue reading →

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The microbiome of plastic tubes in children

Posted on 16 May 2016 by Keith Barrington

Petersen SM, et al. Nasogastric feeding tubes from a neonatal department yield high concentrations of potentially pathogenic bacteria – even one day after insertion. Pediatr Res. 2016.  These authors cultured 94 nasogastric feeding tubes from 34 preterm infants. 1 ml … Continue reading →

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Neonatal Updates

Posted on 16 May 2016 by Keith Barrington

Raina A, et al. Treating perinatal asphyxia with theophylline at birth helps to reduce the severity of renal dysfunction in term neonates. Acta Paediatrica. 2016. This was an RCT in 160 full-term babies with perinatal asphyxia and encephalopathy. Babies, who … Continue reading →

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Is breast-milk really best?

Posted on 11 May 2016 by Keith Barrington

Although many people (including myself) are convinced that human breast milk is the preferable nutrition for human babies, including the preterm, some of the evidence regarding benefits is shaky. For example the evidence that breast milk feeding reduces late-onset sepsis. … Continue reading →

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Erythropoietin for Asphyxia

Posted on 9 May 2016 by Keith Barrington

A preliminary RCT in babies undergoing therapeutic hypothermia (Wu YW, et al. High-dose Erythropoietin and Hypothermia for Hypoxic-Ischemic Encephalopathy: A Phase II Trial. Pediatrics. 2016). They randomized 50 babies with HIE who were being cooled to 1000 units/kg on days 1,2,3,5, … Continue reading →

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Necrotizing Enterocolitis: manipulating the microbiome, part 3

Posted on 9 May 2016 by Keith Barrington

Abdulkadir B, et al. Stool bacterial load in preterm infants with necrotising enterocolitis. Early Hum Dev. 2016;95:1-2.  More work from the Newcastle group, this time the group decided not to look at the proportion of different bugs in the stools, … Continue reading →

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Which Surfactant is best?

Posted on 5 May 2016 by Keith Barrington

Singh N, et al. Comparison of animal-derived surfactants for the prevention and treatment of respiratory distress syndrome in preterm infants. Cochrane database of systematic reviews (Online). 2015;12:CD010249. This is the sort of systematic review that I find really helpful. Some … Continue reading →

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